c-myc癌基因在原发皮肤恶性黑色素瘤中的扩增与表达  

C-myc Oncogene Amplification and Expression in Primary Skin Melanoma

作　　者：黄玲[1] 

机构地区：[1]大理学院附属医院皮肤科,云南大理671000

出　　处：《大理学院学报（医学版）》2002年第2期24-25,31,共3页

摘　　要：目的 :为探讨c-myc癌基因在恶黑中的扩增与表达。方法 :采用原位杂交和免疫组化法检测了c -myc癌基因的扩增和p62myc的表达。结果 :发现恶黑中无c -myc扩增。无转移的浸润性恶黑中 ,p62myc阳性率为82 14% ,伴淋巴结转移的浸润性恶黑阳性率为83 33 %。两者间无显著差异。但两者表达强度分别为80 00 %和57 17 % ,伴淋巴结转移组高于无转移组。结论 :p62myc高强度表达可能与恶黑转移有关。Objective:To study the level of c-myc oncogene amplification and p62myc expression in skin primary malignant melanoma.Methods:c-myc oncoge neamplification and p62myc expression were examined by immunohistochemistry and in situ hybridization respectively.Results:The positive rate of p62myc was 82.14%in tumor tissue without lymphaden metastasis but it was 83.33%in no metastatic malignant melanoma.There was no sufficient difference between two groups.The expressed intensity in this two group were 80% and 57.17% respectively.The expressed intensity of the group with lymphaden metastasis was higher than that of the other one Conclusion:p62myc high intensity expression maybe involved in the metastasis of malignant melanoma.

关 键 词：C-MYC癌基因 原发皮肤恶性黑色素瘤 原位杂交 免疫组织化学 淋巴结转移 p62myc 基因扩增 基因表达 

分 类 号：R739.5[医药卫生—肿瘤]