血管生长抑制剂TNP-470合并放射增敏治疗肿瘤的研究  

Observation on the combinative effect of angiogenesis inhibitor TNP-470 and radiosensitizer in fractionized radiotherapy of a xenograft tumor model

作　　者：管宏[1] 赵慧云[2] 沈磊[2] 李五岭[2] 

机构地区：[1]第二医科大学细胞调控研究室,上海200025 [2]北京大学医学部基础医学院放射医学基础教研室

出　　处：《中华放射医学与防护杂志》2003年第2期96-97,共2页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的　观察血管生长抑制剂TNP 470与放射增敏剂MISO在放疗中联合应用治疗肿瘤的效果。方法　以Lewis肺癌荷瘤小鼠模型比较TNP 470与增敏放疗联合的治疗方法与其他相应各对比治疗方法的差异。结果　TNP 470与放射增敏剂MISO在放疗中联合应用的治疗效果要明显好于其他治疗方法。结论　血管生长抑制剂TNPObjective\ To examine the combinative anti\|tumor effect of angiogenesis inhibitor TNP\|470 and radiosensitizer MISO in radiotherapy. Methods\ A 6\|group in vivo experiment was conducted to evaluate the effects of TNP\|470 combining γ\|irradiation with or without MISO in the C57 mice bearing Lewis lung cancer. Results\ TNP\|470 combined with γ\|irradiation and MISO showed the best therapeutic effectiveness in vivo . Conclusion\ Angiogenesis inhibitor TNP\|470 could potentiate the efficacy of radiosensitizer in radiotherapy.\;

关 键 词：肿瘤 放射治疗 血管生长抑制剂 TNP-470 放射增敏剂 MISO 

分 类 号：R730.5[医药卫生—肿瘤]