^(89)锶联合中药骨瘤方治疗乳腺癌多发性骨转移瘤的临床观察  

Clinical Observation on Treatment of Multiple Bone Metastatic Tumor of Mammary Cancer by Combination Therapy of ^(89)Sr and Chinese Herbal Medicine

作　　者：刘枫[1] 刘淑华[1] 任志刚[1] 刘致俊[1] 

机构地区：[1]广州市肿瘤医院广州医学院临床肿瘤研究中心核医学科,广州510095

出　　处：《中国中西医结合杂志》2003年第4期265-267,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的 :比较89锶 (89Sr)和89Sr联合中药骨瘤方治疗乳腺癌多发性骨转移瘤的疗效。方法 :采取随机抽样分组方法 ,分别应用89Sr及89Sr联合中药骨瘤方治疗乳腺癌多发性骨转移瘤患者 86例和 4 0例 ,观察治疗后骨痛缓解和生活质量的情况 ,比较其转移病灶骨代谢的变化以及对骨髓造血功能的影响。结果 :89Sr和89Sr联合骨瘤方止痛有效率分别为 83 72 %和 95 0 0 % (P >0 0 5 ) ;生存质量的提高稳定率分别为 80 2 3%和95 0 0 % (P <0 0 5 ) ;转移病灶骨代谢治疗后有效率分别为 5 9 30 %和 5 2 5 0 % (P >0 0 5 ) ;血液毒性反应分别为 2 8 0 0 %和 30 0 0 % (P >0 0 5 )。结论 :89Sr联合中药骨瘤方治疗乳腺癌多发性骨转移瘤 ,可加强治疗骨痛的作用及提高患者的生存质量 ,而且不增加血液毒性反应 ,是一种疗效较好的联合治疗方法。Objective:To compare the clinical curative effects between 89 Sr and its combination with the Guliu recipe (GLR, a Chinese herbal medicine) in treating multiple bone metastatic tumor of mammary cancer (MBM-MC). Methods:By adopting the random sampling and grouping method, 89 Sr alone (Sr) and 89 Sr combined with CHM (Sr-GLR) were used in treating 86 and 40 patients with MBM-MC respectively. The efficacy of therapy were appraised according to the degree of ostalgia relieving and quality of life (QOF) in patients, and the effect of treatment on focal bone metabolism and bone marrow hematopoietic function were compared. Results:The effective rate of Sr and Sr-GLR in relieving ostalgia was 83.72% and 95.00%, respectively (P>0.05), the QOF improving and stabilizing rate of them 80.23% and 95.00% (P<0.05), the effective rate on focal bone metabolism 59.30% and 52.50% (P>0.05) and their hemo-toxicity 28.00% and 30.00% (P>0.05). Conclusion:Sr-GLR is a combination therapy in treating MBM-MC with good effect, it could raise the patient′s QOF, enhance the ostalgia relieving effect without increasing the hemo-toxicity of treatment.

关 键 词：乳腺癌 骨转移瘤 ^89锶 ^89SR 中药汤剂 

分 类 号：R737.9[医药卫生—肿瘤] R273.79[医药卫生—临床医学]