肝纤退黄方合654-2注射液治疗肝硬化伴顽固性黄疸临床观察  

Clinical Observation of the Treatment of 654-2 Injection and "GanXian Tui Huang Recipe" on Liver Cirrhosis with Intractable Jaundice

作　　者：杨宏志[1] 郭康寿[2] 沈伟生[3] 李永伟[1] 戴敏[1] 

机构地区：[1]中山大学附属三院,广州510630 [2]广东省吴川市人民医院,吴川524500 [3]江苏省江阴市第二人民医院,江阴214400

出　　处：《中药材》2003年第5期385-387,共3页Journal of Chinese Medicinal Materials

基　　金：广东省科学委员会科研重大项目NO.9703;广东省中医药管理局课题资助项目NO.97222

摘　　要：目的:观察肝纤退黄方合654-2注射液治疗肝硬化伴顽固性黄疸的疗效,并进行理论探讨。方法:选择60例透明质酸(HA)大于400 ng/ml以上同时伴有一氧化氮(NO)增高的肝硬化伴黄疸患者,随机分为实验组和对照组观察治疗3个月。实验组用肝纤退黄方合654-2注射液治疗,对照组用常规疗法。结果:实验组可明显使胆红素(TB)多数复常,球蛋白(GLB)、HA、NO降至接近正常水平;40％门静脉原宽度缩小,50％维持不变;30％脾厚度缩小,40％不变。1年后随访:实验组22例中20例上述指标保持稳定;2例复发;对照组24例中7例保持稳定,10例发生脾功能亢进,2例发生肝癌,5例再发。结论:肝纤退黄方合654-2注射液治疗肝硬化伴顽固性黄疸具有良好疗效。Obiective:To observe the effect of 654-2 injection and ' GanXian Tui Huang Recipe' on hepatic fibrosis with intractable jaundice. Methods:60 patients were treated for 3 months and randomly divided into control group and experiment group. The experiment group was treated with 654-2 injection and 'Gan Xian Tui Huang Recipe' and the control group was treated with routine treatment. All the patients have high level of Nitrogen monoxide (NO) , hyaluronic acid (HA >400 ng/ml)and hepatic fibrosis with intractable jaundice. Results:In experiment group,the serum total bilirubin(TB) ,globulin(GLB) ,HA and NO were significantly decreased to normal level;40% of portal veins were narrowed,50% of them were not changed;30% of spleen were thinned,40% of them were fixed. 1 year later,20 patients were stable and 2 patients were recurrent in 22 patients of the experiment group;in 24 patients of the control group, 7 patients were stable, 10 patients had hypersplenia, 2 patients occurred hepatocarcinoma and 5 patients were recurrent Conclusion:Effect of 654-2 injection and 'Gan Xian Tui Huang Recipe' on hepatic fibrosis with intractable jaundice is significant.

关 键 词：肝纤退黄方 654—2注射液 肝硬化 顽固性黄疸 治疗 疗效 

分 类 号：R575.2[医药卫生—消化系统]