某些还原性生物分子对竹红菌甲素敏化产生~1O_2的抑制作用  

Inhibition of Singlet Oxygen Production from Photosensitized Hypocrellin A by Reducing Biological Molecules

作　　者：王能辉[1] 安静仪[1] 蒋丽金[1] 

机构地区：[1]中国科学院感光化学研究所,北京100101

出　　处：《化学学报》1992年第9期905-909,共5页Acta Chimica Sinica

基　　金：国家自然科学基金

摘　　要：存在还原性的生物分手如甲硫氨酸、尿酸和还原性谷胱甘肽时,竹红菌甲素经受单电子还原形成甲素的半醌自由基、在去氧溶液中观察到了甲素半醌负离子自由基的ESR信号.在充氧的溶液中检测到了超氧负离子自由基.还原剂的存在降低了单重态氧的生成并引起了超氧负离子自由基的生成.Hypocrellin A underwent one-electron reduction to form semiquinone radical anion in the presence of reducing biological molecules such as methione, uric acid and reduced glutathione. The ESR signals of Hypocrellin A semiquinone radical anion were observed in the deaerated solution. The superoxide anion radical was detected in the aerated solution. The singlet oxygen production was decreased and superoxide anion radical production was initiated in the presence of reducing agents.

关 键 词：竹红菌甲素 敏化氧化 单重态氧 

分 类 号：R914.4[医药卫生—药物化学]