p27^(kip1)和Cyclin E在子宫内膜癌表达的临床病理意义  

The Clinical and Pathological Significance of p27^(kip1) and Cyclin E Expressions in Endometrial Carcinoma

作　　者：董丽[1] 李静波[2] 蔡知天[1] 宫桂兰[1] 

机构地区：[1]吉林大学中日联谊医院妇产科 [2]吉林大学第二医院妇产科

出　　处：《吉林大学学报（医学版）》2003年第3期319-321,共3页Journal of Jilin University：Medicine Edition

摘　　要：目的 :研究 p2 7kip1和 Cyclin E在子宫内膜癌组织的表达以及与临床病理参数的关系 ,探讨其在肿瘤发生、发展及预后的意义。方法 :采用免疫组化 S- P法检测 p2 7kip1和 Cyclin E在正常子宫内膜 ( 8例 )、子宫内膜不典型增生 ( 8例 )和子宫内膜癌 ( 5 2例 )组织中的表达。结果 :1 p2 7kip1和Cyclin E阳性表达主要定位于细胞核 ,与正常子宫内膜和内膜不典型增生组织相比 ,p2 7kip1在子宫内膜癌的表达明显下降 ,Cyclin E明显上升 ,差异具有显著性 ,在内膜癌中 p2 7kip1与 Cyclin E蛋白表达呈负相关 ( r=- 0 .30 2 6,P<0 .0 5 )。 2 p2 7kip1和 Cyclin E蛋白表达与内膜腺癌组织学分化程度和肿瘤肌层浸润程度或有无淋巴结转移有关 ,与病理类型无关 ;Cyclin E表达高低也与临床分期和 5年生存率有关。结论 :p2 7kip1表达降低和 (或 ) Cyclin E过度表达与子宫内膜癌的发生发展有关 ,CyclinObjective: The expression of p27 kip1 and Cyclin E were examined to determine the role of these proteins in the pathogenesis, development and prognosis of endometrial carcinoma. Methods: Immunohistochemical S P was performed on normal endometrial(8 cases), endometrial dysplasia (8 cases) and endometrial carcinoma (52 casas)to examine the expressions of p27 kip1 and Cyclin E. Results: ① Immunoreaction of p27 kip1 and Cyclin E were localized mainly in the nuclei of cells. p27 kip1 expression fell significantly in endometrial carcinoma compared with normal endometrial and endometrial dysplasia, while Cyclin E expression rised significantly. p27 kip1 expression was inversely correlated with Cyclin E expression in endometrial. ② The expressions of P27 kip1 and Cyclin E were significantly associated with adenocarcinoma cell differentiation, muscles invasion or lymph node metastasis, but not related to pathological types. Cyclin E expression was also associated with clinical stage and 5 year survival of patients. Conclusion: p27 kip1 low expression and/or Cyclin E overexpression were involved in the genesis and development of endometrial carcinoma, and Cyclin E might be indications to predict the prognosis of endometrial carcinoma.

关 键 词：予宫内膜肿瘤 P27KIP1 细胞周期蛋白E 细胞周期 

分 类 号：R737.33[医药卫生—肿瘤] R730.4[医药卫生—临床医学]