间断低氧大鼠谷胱甘肽过氧化物酶及还原型谷胱甘肽的变化  

The Changes of Glutathione Peroxidase and Reduced Glutathione in Intermittently Hypoxic Rats

作　　者：杨文波 孙仁宇[1] 严仪昭[1] 张宏[1] 

机构地区：[1]中国医学科学院基础医学研究所,北京100005

出　　处：《基础医学与临床》1992年第5期284-287,共4页Basic and Clinical Medicine

摘　　要：动态测定了常压间断低氧大鼠全血和肺组织谷胱甘肽过氧化物酶(GSH-PX)活性及还原型谷胱甘肽(GSH)含量。结果发现随低氧时间延长,肺动脉压逐渐升高的过程中有全血及肺组织GSH-PX活性及GSH含量的显著降低。维生素E和山莨菪碱有部分保护作用。提示间断低氧过程中活性氧自由基生成增多,消耗了较多的抗氧化酶(剂)。氧自由基生成增多可能在其肺动脉高压的发生中起一定作用。Glutathione peroxidase (GSH-PX) activities and redused glutathione (GSH) contents of blood and lung parenchyma were measured during intermittent exposure to hypoxia in rats. It was found that GSH-PX activities and GSH contents were significantly decreased with increase of pulmonary arterial pressure caused by hypoxia. Vit E and Anisodamine have some alleviatory effect on above changes. The results suggestad that in the process of intermittently hypo-xic pulmonary hypertension in rats, generation of oxygen free radicals in lung tissue increased, which may play a role in pathogenesis of pulmonary hypertension.

关 键 词：谷胱甘肽 过氧化物酶 肺动脉高压 

分 类 号：R361.3[医药卫生—病理学]