根除幽门螺杆菌对胃黏膜肠化生的影响  

Effect of Helicobacter pylori eradication on intestinal metaplasia in chronic gastritis

作　　者：李根武[1] 伍灵达[1] 王菊岩[2] 

机构地区：[1]广东医学院附属医院消化内科,广东湛江524001 [2]广东医学院附属医院内镜室,广东湛江524001

出　　处：《广东医学院学报》2002年第4期266-267,共2页Journal of Guangdong Medical College

摘　　要：目的 :了解幽门螺杆菌 (HP)感染伴胃黏膜肠化生者经根除 HP后肠化生的变化情况。方法 :HP感染伴肠化生者 2 8例口服抗菌药物三联疗法 1 4 d,另 2 1例不予根除 HP,6个月后复查胃镜和病理活检。结果 :2 8例中 2 4例 HP获根除 ,肠化生消失或明显减轻者有 1 1 /2 4例 ,对照组仅有 3/ 2 1例 ,两组差异具有显著性 (P<0 .2 5)。结论 :根除 HP后肠化生可有效地消除或明显减轻 ,认为当 HP感染伴肠化生时应积极根除 HP。Objective:To observe the effect of Helicobacter pylori (HP) eradication on intestinal transdifferentiation in chronic gastritis.Methods:Forty nine patients with helicobacter associated chronic gastritis and intestinal metaplasia were divided into two groups:treatment group( n =28) receiving triple antibiotics for 3 weeks, while control group( n =21)not .All patients undertook again gastroscopy and biopsy 6 months later.Results:HP was eradicated in 24 and 0 in treatment and control groups,respectively.There was an obvious difference in the disappearance or improvement of intestinal metaplasia between two groups( P <0.05).Conclusion:Eradication of HP may prevent the progression of intestinal metaplasia in chronic gastritis. It is suggested that HP should be actively treated in patients with helicobacter associated chronic gastritis and intestinal metaplasia. [

关 键 词：幽门螺杆菌 胃黏膜肠化生 影响 药物疗法 

分 类 号：R573.3[医药卫生—消化系统]