万拉法新与氟西汀治疗精神分裂症后抑郁对照研究  

A comparative study of vanlafaxine and fluoxetine in the treatment of post-schizophrenic depression

作　　者：刘玉厚[1] 冯伟[1] 徐敏秀[1] 

机构地区：[1]山东省临沂市精神卫生中心,山东临沂276005

出　　处：《中国民康医学》2003年第6期327-329,共3页Medical Journal of Chinese People’s Health

摘　　要：目的 :比较万拉法新与氟西汀治疗精神分裂症后抑郁的疗效及安全性。方法 :将符合 (CCMD - 2 -R)精神分裂症后抑郁诊断标准的 6 8例患者随机分为两组 ,分别给予万拉法新和氟西汀治疗 ,疗程 6周。采用汉密尔顿抑郁量表 (HAMD)、简明精神病量表 (BPRS)、阴性症状量表 (SANS)评定临床疗效 ,采用副反应量表 (TESS)评定副反应。结果 :万拉法新组与氟西汀组治疗前后HAMD、BPRS、SANS评分及减分比较差异均无显著性 (P >0 0 5 )。两组副反应发生率比较亦差异无显著性 (P >0 0 5 )。结论 :万拉法新治疗精神分裂症后抑郁的疗效确切 ,其疗效和副反应均与氟西汀相当。Objective:To determine the efficacy and side effects of vanlafaxine and fluoxetine in the treatment of patients with post schizophrenic depression Methods:68 patients who met the CCMD-2-R criteria of post schizophrenic depression were randomly assigned to vanlafaxine group and fluoxetine group for the treatment of 6 weeks The efficacy were assessed by Hamilton Depression Rating Scale(HAMD),Brief Psychotic Rating Scale(BPRS)and the Scale for Assessment of Negative Symptoms(SANS) The side effects were assessed by Treatment Emergent Symptoms Scale(TESS) Results:There was no significant difference in efficacy and side effects between the two groups(P>0 05) Conclusion:Vanlafaxine is an effective drug in the treatment of post schizophrenic depression Fluoxetine and vanlafaxine were similar in their efficacy and side effects

关 键 词：万拉法新 氟西汀 精神分裂症 疗效 安全性 副反应量表 抑郁 治疗 阴性症状量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]