电脉冲结合盐酸阿霉素对小鼠S180肉瘤的抑制作用  

The Inhibit Effect of Electric Pulse Combined with Adriamycin (ADR) on Mice S180 Sarcoma

作　　者：耿芹[1] 王子淑[1] 邹方东[1] 岳碧松[1] 李虹[1] 郭聪[1] 王保义[2] 张弘[2] 曾浩[2] 

机构地区：[1]四川大学生命科学学院,成都610064 [2]四川大学无线电系,成都610064

出　　处：《四川大学学报（自然科学版）》2003年第3期586-589,共4页Journal of Sichuan University(Natural Science Edition)

基　　金：国家自然科学基金(60071024)

摘　　要：用低强度电脉冲结合低剂量盐酸阿霉素局部给药,研究了小鼠S180肉瘤的治疗情况,将荷瘤昆明小白鼠随机分为对照组、药物组、电场组和电场+药物组,分别从肿瘤生长状况、组织化学等方面进行实验观察.结果表明,电脉冲结合盐酸阿霉素治疗肿瘤有协同增效作用.The study was performed for testing the effect of electric pulse combined with adriamycin(ADR) to treat S180 sarcma of mice.Kunming mice were randomly divided into 4 experimental groups after inoculation of S180 sarcoma:control group,drug group,electric pulse group and drug plus electric pulse group.The result of sarcoma measure indicated that the growth rates of sarcomas of the drug plus electric pulse group were significantly inhibited compared with other groups.And the result of histochemical observation indicated that the structures of sarcoma cells of drug plus electric pulse group had more damages than that of other groups.Therefore,the authors conclude that the electric pulse could enhance the effect of ADR.

关 键 词：电脉冲 盐酸阿霉素 S180肉瘤 昆明小鼠 

分 类 号：R730.5[医药卫生—肿瘤]