肿瘤与结核标志蛋白整合技术对卵巢恶性肿瘤患者预后的判定作用(英文)  

Effect of tumor and tuberculosis marker proteins integrated technology in the judgement of prognosis of patients with ovary malignant tumors

作　　者：胡娟[1] 魏敏[1] 张鸣山[2] 谭映军[2] 曾化松 任伟 景秀京 胡宗海 

机构地区：[1]解放军第三军医大学成都军医学院军事预防医学教研室,四川省成都市610083 [2]解放军成都军区总医院科研科,四川省成都市610083 [3]武装警察部队四川总队成都医院科研科,四川省成都市610041

出　　处：《中国临床康复》2003年第11期1656-1657,共2页Chinese Journal of Clinical Rehabilitation

基　　金：2000年四川省教育厅重点课题(000221)~~

摘　　要：目的分析卵巢恶性肿瘤患者血清CA125水平和SA/ATM二联标志蛋白表达信息,探讨双联整合技术用于临床康复鉴别诊断的临床价值。方法经核磁共振氢谱NMR1H仪捕获49例结核性腹膜炎ATM-Pr谱学特征,用生化显色法和磁分离酶免疫法检测101例卵巢恶性肿瘤,985例其他妇科疾患血清标志蛋白,进行对比分析。结果血清CA125和SA水平在卵巢恶性肿瘤和结核性腹膜炎组均明显升高(差异无显著性,P>0.05);>子宫颈癌>子宫肌瘤、卵巢良性肿瘤、单纯性卵巢囊肿、盆腔炎性包块;血清ATM-Pr谱学特征显示:卵巢恶性肿瘤和结核性腹膜炎在信息特征峰表达上有明显差异(P<0.01)。结论SA和CA125在卵巢恶性肿瘤诊断中有较高准确性,但特异性受结核疾病干扰。SA/ATM双联检测可有效用于肿瘤/结核的筛查和鉴别,有较好的特异性,方法快捷更具早发现适用性,并可作为临床康复判定的指标之一。Aim To discuss the clinical value of coupled integrated technology used into differential diagnosis of clinical rehabilitation,we analyzed the levels of serum CA125 and message expressed by SA/ATM coupled marker protein in patients with ovary malignant tumors.Methods The characteristics of ATM Pr Maps of 49 patients with tuberculous peritonitis were captured with Nuclear Magnetic Resonance Hydrogen(NMR1H) Map Device,serum marker proteins of 101 patients with ovary malignant tumors and 985 patients with other gynecopathys were determined through biochemical coloration and magnetic separating enzyme immunological method, and then the data were compared and analyzed.Results The levels of serum CA125 and SA in patients with ovary malignant tumors or tuberculous peritonitis both increased obviously(the difference wasn't significant,P >0.05); the characteristics of serum ATM Pr Maps of patients with carcinoma of uterine cervix,hysteromyoma ovary benign tumor,simple oophoritic cyst and pelvic inflammatory mass showed that there was significant difference in expression of massage characteristic peak between patients with ovary malignant tumor and those with tuberculous peritonitis(P< 0.01). Conclusios SA and CA125 are more sensitive in the diagnosis of ovary malignant tumors,but their specificity is affected by tuberculosis.SA/ATM coupled determination may be used into screening and differentiation of tumor/tuberculosis effectively.This method is more specific,very convenient to operate,and more suitable for early detection,too.As a result,it could be one judgmental indicator of clinical rehabilitation.

关 键 词：卵巢恶性肿瘤 CA125 SA ATM 结核性腹膜炎 康复 鉴别诊断 血清标志蛋白 预后 

分 类 号：R737.31[医药卫生—肿瘤] R526[医药卫生—临床医学]