英卡膦酸二钠治疗恶性肿瘤骨转移疼痛15例  

Incadronate in the treatment of pain in 15 patients with metastatic tumor of bone

作　　者：秦凤展[1] 郑荣生[1] 翟云芝[1] 孙惠娟[1] 吴穷[1] 毕明宏[1] 

机构地区：[1]安徽省肿瘤医院,蚌埠233004

出　　处：《中国新药杂志》2003年第5期380-382,共3页Chinese Journal of New Drugs

摘　　要：目的 :评价注射用英卡膦酸二钠治疗恶性肿瘤骨转移疼痛的疗效和安全性。方法 :共入选 31例患者 ,随机分为试验组 15例和对照组 16例。试验组用英卡膦酸二钠 10mg加入生理氯化钠溶液 5 0 0mL ,静滴 3～ 4h ;对照组用帕米膦酸二钠 90mg加入生理氯化钠溶液 5 0 0mL ,静滴 6h。 2组均单次给药后观察 2 1d。 结果 :骨转移疼痛有效率试验组为 6 6 .6 7% (显效 2例 ,有效 8例 ) ,对照组为 75 .0 0 % (显效 0例 ,有效 12例 ) ,2组疗效无统计学差异 (P >0 .0 5 )。 2组不良反应发生率分别为 18.75 %和 5 6 .2 5 % ,均为Ⅰ～Ⅱ度发热 ,经对症处理后好转。试验组不良反应发生率较低 ,但 2组无显著差异 (P =0 .0 6 5 9)。结论 :英卡膦酸二钠为新一代骨吸收抑制剂 ,对骨转移所致疼痛有较好的止痛效果且安全。Objective:To evaluate the safety and efficacy of incadronate in treatment of pain in patients with metastatic tumor of bone.Methods:31 patients were recruited into the study.15 of them were randomly allocated to receive 10 mg incadronate infusion for 3～4 hours,the balance of them were allocated to receive 90mg pamidronate infusion for 6 hours.Results:The effective rate was 66.67%(10/15)in active group and 75.00%(12/16) in control group.No significant difference was observed between two groups.The incidence rate of pyrexia(Ⅰ～Ⅱdegree) was 18.75% in active group and 56.25% in control group with no significant difference between groups.Conclusion:Incadronate is a new kind of bone absorption inhibitor.It is effective and safe in treatment of pain in patients with metastatic tumor of bone.

关 键 词：英卡膦酸二钠 帕米膦酸二钠 骨转移疼痛 恶性肿瘤 治疗 

分 类 号：R730.5[医药卫生—肿瘤] R441.1[医药卫生—临床医学]