伴发生活事件的抑郁症患者临床疗效观察  

Fluoxetine in Treatment of Depression with Stress

作　　者：刘平 肖计划 郑安琳[3] 汪士昌[4] 陈瑞英[4] 李雪霓[5] 曹奕[3] 贾艳滨 唐登华[5] 郑晔 史蔚 

机构地区：[1]礼来研究中心,上海西藏中路18号16层200001 [2]广州暨南大学华侨医院 [3]上海华东医院 [4]北京大学第一医院 [5]北京大学第六医院

出　　处：《中国心理卫生杂志》2003年第6期418-420,共3页Chinese Mental Health Journal

摘　　要：目的 :验证氟西汀治疗出现于明显生活事件之后的抑郁症的效果。方法 :62例最近一年内生活事件量表 (LES)得分 >3 0的抑郁症病人采用氟西汀治疗 6周。结果 :治疗结束时Hamilton抑郁量表(HAMD)总分自基线的 2 2 63± 4 2 3下降到 9 97± 5 86(P <0 0 0 1)。Hamilton焦虑量表总分 (HAMA)总分自基线的 2 3 13± 5 3 2下降到 10 2 4± 6 41(P <0 0 0 1)。与此同时 ,HAMD睡眠因子和临床严重度总体印象得分也显著下降。各疗效指标的改善在治疗第二周即达到统计学显著水平。不良反应轻微 ,较多见的有食欲减退、口干、恶心等 ,不影响治疗。结论 :氟西汀可有效治疗伴发于明显生活事件的抑郁症患者 ,且起效较快 ,不良反应小。Objective: To confirm the effectiveness of fluoxetine in treatment of depression associated with apparent life events Method: Sixty-two depressive patients who had a total score of the Life Event Scale of more than 30 were treated with fluoxetine for 6 weeks, diazepam was added if necessary CGI, HAMD and HAMA were used to assess the result Result: At the endpoint, the total score of HAMD decreased from 23±4 at baseline to 10±6, the total score of HAMA was also decreased significantly (23±5 to 10±6) At the meantime, the HAMD sleep factor and CGI severity score were also decreased significantly All above measurements showed improvement at the first week of treatment The adverse effects were mild, with lose of appetite, dry mouth and nausea as the most frequently seen, which had no influence on treatment process Conclusion: Fluoxetine plus diazepam is effective in depressive patients with apparent life events with quick response and mild adverse effects

关 键 词：抑郁症 生活事件 氟西汀 临床疗效 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]