结直肠癌临床病理特征与预后的多因素回归分析  

Multi-variate regression analysis of clinicopathological characteristics and prognosis of colorectal cancer

作　　者：汪建平[1] 杨祖立[1] 王磊[1] 董文广[1] 黄奕华[1] 覃建章[1] 詹文华[1] 

机构地区：[1]中山大学第一附属医院胃肠胰腺外科,广州510080

出　　处：《中华肿瘤杂志》2003年第1期59-61,共3页Chinese Journal of Oncology

基　　金：广东省科委攻关基金资助项目(1997010)

摘　　要：目的探讨结直肠癌的临床病理特征与预后的关系。方法应用单因素和多因素的分析方法,回顾性分析有完整临床病理资料和随访资料的761例结直肠癌患者的临床特点、病理特征及其对预后的影响。结果结直肠癌患者总的3,5年生存率分别为62.9％和60.7％,中位生存时间为1825 d。单因素分析显示,其预后与肿瘤的大体分型、侵袭程度、转移情况、分化等级、病理分期以及癌性肠梗阻均有相关性。应用Cox比例危险回归模型分析显示,肿瘤的大体分型、分化程度、肠壁的侵袭深度和病理分期是影响结直肠癌患者术后生存的独立因素。结论病理分期是影响结直肠癌患者预后最重要的一个指标(P<0.0005),对于指导手术治疗、术后辅助治疗和判断预后方面具有重要作用。Objective To evaluate the relationship between clinicopathologic features and prognosis of colorectal cancer after surgical treatment. Methods The clinical characteristics, pathologic features and survival rate of 761 patients with colorectal cancer after surgical treatment were univariately and multivariately analyzed. Results The overall 3-and 5-year survival rates of patients with colorectal cancer after surgical treatment were 62.9% and 60.7% with a median survival of 1 825 days. The factors of gross findings, degree of differentiation, infiltration, nodal and distant metastasis and neoplastic intestinal obstruction influenced the survival rate by univariate analysis. The factors of Dukes stage, gross tumor configuration, intramural spread and differentiation degree were available independent prognostic factors through multivariate analysis. Conclusion Dukes stage, as the most important available independent prognostic factor( P < 0.000 5), is able to assess the postoperative survival.

关 键 词：结直肠癌 临床病理特征 顶后 多因素回归分析 

分 类 号：R735.3[医药卫生—肿瘤]