化疗后早期应用粒生素的疗效观察  

A Clinical Investigation on Early Application of rhG-CSF after Chemotherapy

作　　者：路太英[1] 周云[1] 

机构地区：[1]郑州大学第一附属医院肿瘤科,河南郑州450052

出　　处：《河南肿瘤学杂志》2003年第3期166-167,共2页Henan Journal of Oncology

摘　　要：目的　探讨化疗后早期应用重组人粒细胞集落刺激因子 (rhG -CSF ,粒生素 )对白细胞和粒细胞减少的防治作用。方法　治疗组化疗后 2 4～ 48小时内给予粒生素应用 ;对照组则在白细胞低于正常值时开始给予粒生素应用。结果　治疗组白细胞低于正常值的持续时间明显短于对照组 (P <0 0 5 ) ,且治疗组化疗后感染率明显降低 (P <0 0 5 )。结论　粒生素预防应用可以明显缩短白细胞低于正常值的持续时间 。Objective To investigate the effect of recombined human granulocyte colony-stimulating factor (rhG-CSF) on leukopenia and neutropenia induced by chemotherapy.Methods rhG-CSF began to be used within 24～48 hours after chemotherapy in treatment group,and in control group,rhG-CSF application was started when the blood granulocyte count being low.Results The absolute neutrophil count dropping time was shorter in the treatment group than that in the control group,and the infection rate decreased significantly in the former group.Conclusion This study showed that early treatment with rhG-CSF can decrease the absolute neutrophil count dropping time and infection rate.

关 键 词：化疗 早期 临床应用 粒生素 疗效 重组人粒细胞集落刺激因子 白细胞减少 粒细胞减少 

分 类 号：R730.53[医药卫生—肿瘤]