电磁脉冲辐射对小鼠妊娠和子代的影响  

EFFECT OF ELECTROMAGNETIC PULSE IRRADIATION ON PREGNANCY AND OFFSPRING

作　　者：王水明[1] 王德文[1] 彭瑞云[1] 高亚兵[1] 陈浩宇[1] 曹晓哲[1] 赵梅兰[1] 崔雪梅[1] 

机构地区：[1]军事医学科学院放射医学研究所

出　　处：《解放军医学杂志》2003年第6期520-522,共3页Medical Journal of Chinese People's Liberation Army

基　　金：全军医学科研"十五"计划指令课题资助项目 (编号 0 1L0 2 3)

摘　　要：6～ 8周龄二级雌性昆明小鼠受孕后 6～ 8天接受 6× 1 0 4V/m电磁脉冲 5次重复全身照射或照射后 1 4天内、1 5～ 2 8天受孕 ,在受孕后第 1 8天活杀 ,用足孕期畸形学指标进行分析 ,以探讨电磁脉冲辐射对小鼠妊娠和子代的影响。结果显示 ,电磁脉冲照射后雌鼠体重增加值、大多数脏器重量、脏器 /体重比值均无明显改变 ,但存活子鼠尾长均缩短 ;孕后 6～ 8天照射和雌鼠照射后 1 5～ 2 8天受孕 ,雄性子鼠比例降低 ;雌鼠照射后 1 4天内及 1 5～ 2 8天受孕 ,子鼠体重均下降。辐射组死胎率和胚胎吸收率均较正常对照组增高 ,尤以雌鼠照射后 1 4～ 2 8天受孕最明显 ,分别为对照组的 5 2和 3 8倍。结果表明 ,雌性小鼠无论是受孕前 。Female Kunming mice (6-8 weeks old) were exposed to total body irradiation by of 6×10 4V/m EMP(electromagnetic pulse, EMP) for five times in 6-8th day of gestation(post pregnant irradiation), or became pregnant within 14 days (early conception after irradiation), or 14-28 days (late conception after irradiation) after irradiation. Pregnant mice were killed at 18th day. Teratological markers were analysed to evaluate the effect of EMP irradiation on pregnancy and offspring. The results showed that EMP irradiation caused no significant changes in maternal body weight gains, most of organ weight and organ/body weight ratio. But it caused significant shortening of tail length of live foetus. The offspring sex ratio was decreased after post pregnant irradiation and early conception after irradiation. Body weight was decreased in the early and late conception after irradiation. EMP irradiation also resulted in a significant increase in fetal death rate and embryo absorption rate compared with control group, especially in the late conception group, which was increased 5 2 and 3 8 times respectively. The results suggested that EMP irradiation exerted certain effects on pregnancy and offspring development in both pre pregnant and post pregnant female mice.

关 键 词：辐射 妊娠 动物 

分 类 号：R36[医药卫生—病理学] R594[医药卫生—基础医学]