血管内皮生长因子家族及其受体  

The VEGF Family and VEGFR Receptor Tyrosine Kinases

作　　者：丁明星[1] 何卫妹[1] 李继承[2] 

机构地区：[1]金华职业技术学院医学院 [2]浙江大学医学院

出　　处：《金华职业技术学院学报》2003年第2期35-38,共4页Journal of Jinhua Polytechnic

摘　　要：血管内皮生长因子(VEGF)家族包括VEGF-A,-B,-C,-D,-E和胎盘生长因子(PIGF),都与同型的酪氨酸激酶受体VEGFR-1(Flt1),VEGFR-2(KDR/Flk1)和/或VEGFR-3(Flt4)结合。本文综述血管内皮生长因子家族及其受体在肿瘤血管生成、淋巴管生成及肿瘤转移中的作用。The VEGF family of angiogenic growth f ac tors includes VEGF-A,-B,-C,-D and-E as well as placenta growth factor(P IGF),which activates VEGFR-1(Flt1),VEGFR-2(KDR/Flk1)and/or VEGFR-3(Flt4)receptor tyrosine kinases.Differences in the regulation and tissue istribution of these family members suggest that they have distinct roles both during angiogenesis,lymphangio-genesis and tumor metastasis.

关 键 词：血管内皮生长因子家族 血管内皮生长因子受体 肿瘤转移 (VEGF 胎盘生长因子 酪氨酸激酶受体 

分 类 号：R730.23[医药卫生—肿瘤]