噻二唑类Schiff碱配合物的合成及其对超氧阴离子自由基的抑制活性  

Studies on synthesis and the free radical inhibition rate to superoxide anion of a new schiff base with thiadiazole and their complexes

作　　者：王建华[1] 雷文[2] 王远亮[1] 

机构地区：[1]重庆大学生物力学与组织工程教育部重点实验室,重庆400044 [2]重庆大学化学系,重庆400044

出　　处：《化学研究与应用》2003年第3期335-337,共3页Chemical Research and Application

基　　金：国家自然科学基金项目(19872080)

摘　　要：用2 氨基 5 巯基 1,3,4 噻二唑与水杨醛及氯乙酸合成了Schiff碱及与Cu(Ⅱ)、Co(Ⅱ)、Zn(Ⅱ)的配合物,并由元素分析、红外光谱、紫外可见光谱和摩尔电导等对其进行了表征.核黄素 蛋氨酸光照法进行的活性实验表明配体及配合物均对超氧离子有一定的抑制效果.Copper(Ⅱ),zinc(Ⅱ)and cobalt(Ⅱ)complexes with the Schiff base derived from 2amino5mercapto1,3,4thiadiazole,salicylaldehyde and chloroacetic acid were synthesized and characterized by elemental analysis,IR,UV and molar electrtical conductivity.These complexes were tested for their antisuperoxide anion free radical.The results showed that all of the obtained complexes and the new ligand displayed significant activities and the copper(Ⅱ)complexes showed the best inhibitive effect.

关 键 词：噻二唑类Schiff碱配合物 合成 超氧阴离子自由基 抑制活性 超氧化物歧化酶 模型化合物 席夫碱配合物 

分 类 号：Q554.9[生物学—生物化学]