高压氧对局灶性脑缺血损伤大鼠脑神经功能的影响  

Effect of hyperbaric oxygen on nerve function of brain after focal cerebral ischemia in rats

作　　者：周永清[1] 刘立[1] 任宇红[1] 

机构地区：[1]解放军第四军医大学航空航天医学系临床医学教研室,陕西省西安市710032

出　　处：《中国临床康复》2003年第13期1873-1875,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的广泛应用高压氧(HBO)治疗脑卒中的疗效结果不完全一致。为证实HBO对脑缺血后的神经行为学产生影响的假设,观察HBO治疗前后实验大鼠的肌力及运动功能的变化。方法线栓法建立大鼠的大脑中动脉缺血模型(MCAO);观察脑神经功能的变化。结果HBO治疗后缺血大鼠的神经功能异常恢复较快,缺血HBO组(OH组)缺血6h神经症状评分在(1.22±0.40),较单纯缺血组(O组)(3.00±0.71)明显好转;OH组在缺血后72h网屏测验评分(4.68±0.48)与O组(3.58±0.69)差别有显著性意义(t=5.71,P<0.01);OH组在缺血后3周触觉刺激试验(32.49±7.54)与O组(63.52±14.29)差异有显著性意义(t=8.37,P<0.01);OH组在缺血后2周平衡木行走实验(5.00±0.67)与O组(3.95±0.52)差异有显著性意义(t=5.40,P<0.01)。结论HBO能促进脑缺血损伤后神经功能缺损的恢复。其机制考虑与增加缺血组织的氧供应、减轻脑水肿和减少组织病变有关。Aim To observe the changes of myodynamia and motor function for providing the effect of HBO on the behavior of nerve after focal ischemia in rats.Methods Thirty-eight SD rats were randomly d ivided into two groups of 19cases:simple ischem ia group and HBO group.Unilateral cerebral ischemia was induced in rat s by the middle cerebral artery occlu sion(MCAO).The changes of cerebral nerve function were evaluated by motor function test.Results The nerve symptom scores were(1.22±0.40)6h after ischemia in the HBO group,sign ificantly better than that of the sim ple ischemia group(3.00±0.71).The scores of net screen test were(4.68±0.48)and(3.58±0.69)72h after ischemia in the simple isch emia group and the HBO group respectively(t=5.71,P<0.01).The scores of tactile stimulation test were(32.49±7.54)and(63.514.29)3weeks after is-chemia in the two groups respectively(t=8.37,P<0.01).The scores of balance beam walking test were(5.00±067)and(3.95±0.52)2weeks af-ter ischemia in the two groups respectively(t=5.40,P<0.01).Con-clusion HBO improves the abnormal nerve function evidently.The effect may be related to the increasing of oxygen supply to cerebral ischemic tis sue,and reduction of brain edem and cereb ral ischemic tissue.

关 键 词：高压氧 治疗 脑卒中 局灶性脑缺血损伤 大鼠 脑神经功能 疗效 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R459.6[医药卫生—临床医学]