非霍奇金淋巴瘤中的微血管密度及其临床病理意义  

Clinicopathological significance of microvessel density in Non-Hodgkin's lymphoma

作　　者：黄爱民[1] 翁景萱[1] 高凌云[1] 

机构地区：[1]福建医科大学基础医学院病理学系,福州350004

出　　处：《解剖学杂志》2003年第1期51-54,共4页Chinese Journal of Anatomy

摘　　要：目的:探讨非霍奇金淋巴瘤(NHL)中的微血管密度(MVD)及其与NHL恶性程度、免疫学类型、预后的关系;方法:采用生物素标记的荆豆凝集素I(Bio-UEA-I)免疫组化ABC法对102例NHL的MVD进行原位观察和数量分析;结果:MVD随NHL恶性程度的增高而增高,高度恶性组和中度恶性组MVD显著高于低度恶性组MVD;T细胞性NHL中的MVD显著高于B细胞性NHL也的MVD;短生存期组的MVD显著高于长生存期组的MVD;结论:NHL中的MVD可作为判断肿瘤恶性程度、免疫学类型及预后估计的有意义的指标,在临床病理中有实际应用价值。Objective:To explore the relationship between the microvessel density (MVD) and the malignancy,immuno-types and prognosis of Non-Hodgkin's lymphoma (NHL). Methods:By using biotinated UEA-I (Bio-UEA-I) immunohis-tochemical ABC method,the MVD in 102 cases of NHL were detected. Results: MVD in high grade and middle grade NHL were significantly higher than that in low grade NHL;T cell NHL MVD was apparently higher than B cell NHL MVD,and MVD in short survival group was remarkably higher compared with that in long survival group. Conclusion: MVD in NHL can be a valuable parameter in assessing the malignancy degree,immunotypes and prognosis of NHL.

关 键 词：非霍奇金淋巴瘤 微血管密度 荆豆凝集素I 免疫组织化学 恶性程度 免疫学类型 预后 

分 类 号：R733.1[医药卫生—肿瘤]