不同经纬度肝癌临床特征年周期余弦曲线拟合参数对比  

Comparison of the yearly cycle cosine curve imitative parameters of the clinical features of liver cancer at different longitude and latitude

作　　者：余万霰[1] 左敏静[2] 王正荣[3] 黄河浪[1] 谢梦莉[4] 张宝初[5] 

机构地区：[1]江西医学院公共卫生学院,南昌330006 [2]江西医学院第二附属医院 [3]华西医科大学生物医学工程研究室 [4]江西省气象局 [5]江苏省启东市肝癌研究所

出　　处：《中华肝脏病杂志》2003年第6期347-349,共3页Chinese Journal of Hepatology

基　　金：国家自然科学基金(3936003;39860030)

摘　　要：目的 根据爱因斯坦的“弯曲时空”理论及其场方程定律验证不同经纬度地区肝癌临床易表现 期是否具有同时性。方法 选择三个气候差异很大的不同经纬度地区采样,列出肝癌症状起始月份及临床检测 12个项目,共36个项目分别拟合成年周期余弦曲线(余弦法),对比峰值相位参数及调整中值与振幅的比值,来认 定是否为正比的同等范围。结果 三地区项目在年周期余弦曲线上峰值时相全部出现在-90.1°～-207.5°(4～7 月份),位于年周期的1/3同等范围。三地区中早期影像及谷胺酰转肽酶6个项目峰值相位全部出现在-98.5°～ -148.2°(4～5月份)。13个项目呈现明显节律特征。结论 三个地区肝癌恶性生长存在同一年生物周期模 式,4～7月份为肝癌临床易表现期(中早期在4～5月份),不同气候地区在该期间加强临床检测均可提高 中早期肝癌发现率。Objective To explore whether there exists coincidence of the most appearing time of clinical features of liver cancer at different longitude and latitude, according to the law of field equation and the theory of warpage of space time by Einstein. Methods Three regions with different longitude and latitude were selected randomly and sampled. There were 36 items altogether, including 12 clinical items, which were used to imitate the yearly cycle cosine curve. The acorphases and the ratioes of amplitudes and means were compared to justifying whether they were in the same range. Results All the acorphases of 36 items appeared between -90.1° -207.5° (from april to July), existing in one third of the same range, in which 13 items occurred rhythmly (P < 0.05). The image acorphases of liver cancer at the early and middle stage and r-glutamyl transpeptidase acorphase appeared between -98.5° -148.2° (from april to may), in which 5 items occurred rhythmly (P < 0.05). Conclusions It is the same mode of the yearly biologcal cycle for liver cancer malignant growth within the most appearing time (from april to July). It will increase the detecting rate of liver cancer at the early and middle stage during this time (especially from april to may).

关 键 词：肝癌 临床特征 年周期余弦曲线拟合参数 对比 弯曲时空 

分 类 号：R735.7[医药卫生—肿瘤]