灯盏花素对脑梗死患者超氧化物歧化酶及丙二醛含量的影响  

Effect of breviscapine on SOD and MDA in the cerebral infarction patients

作　　者：张永和[1] 宋祖军[1] 张新睿[1] 

机构地区：[1]中国人民解放军第四军医大学西京医院急诊科,陕西西安710032

出　　处：《中国急救医学》2003年第6期394-395,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　探讨灯盏花素注射液对脑梗死患者血清超氧化物歧化酶 (SOD)及丙二醛 (MDA)含量变化的影响。方法　 32例脑梗死患者在综合治疗的基础上经静脉给予灯盏花素注射液治疗 ,治疗前及用药后 1、3、5、7、1 0d取外周静脉血检测血清SOD及MDA的含量 ,并与正常对照组进行对比分析。结果　脑梗死患者血清的SOD及MDA含量均明显高于正常对照组 (P <0 0 1 ) ;应用灯盏花素注射液治疗后 ,患者血清SOD及MDA水平均有不同程度下降 ,至 1周后与用药前比较有显著性差异 (P <0 0 1 )。Objective To study the effect of breviscapine on the change of serum superoxide dismutase (SOD) and malonyl-dialdehyde (MDA) in cerebral infarction patients. Methods 32 cerebral infarction patients were treated with breviscapine given through venous in addition to general treatment. The concentration of tumor necrosis factor (SOD) and interleukin-6 (MDA) in serum were measured respectively before and during the treatment of 1, 3, 5, 7, 10 d,and control group was observed simultaneously. Results The concentration of SOD in serum of cerebral infarction patients was lower but MDA was higher than that in control group (P<0 01) The levels of SOD were decreased but MDA were increased by the treatment of breviscapine, and that was obvious after the treatment in one week. Conclusion Breviscapine had an antagonism against superoxide response in cerebral infarction.

关 键 词：脑梗死 灯盏花素 超氧化物歧化酶 丙二醛 

分 类 号：R743.33[医药卫生—神经病学与精神病学]