The Expression and Clinical Significance of Fas and FasL in Lung Cancer  

肺癌组织Fas和FasL表达及临床意义(英文)

作　　者：董西林[1] 董蕾[1] 李秀霞[1] 李朝霞[1] 王雅娟[1] 

机构地区：[1]西安交通大学第二医院内科

出　　处：《Journal of Nanjing Medical University》2003年第3期122-128,共7页南京医科大学学报（英文版）

摘　　要：Objective: To investigate the expression and clinical significance of Fas andFasL in lung cancer. Methods: SP immunohistochemical technique was used to detect the expression ofFas and FasL in 46 cases of lung cancer and 30 cases of adjacent non-neoplastic tissue. Results:Down-regulation, of Fas and up-regulation of FasL were found in lung carcinoma. The levels of Fasexpression in squamous cell carcinoma, adenocarcinoma and SCLC were significantly lower than that ofadjacent normal tissues (P<0. 01) , while the expression levels of FasL were the opposite (P< 0.05). Fas expression was associated with high histological grade and no metastasis (P<0. 05). FasLexpression was related to histological grade, late clinical stage and metastasis (P<0. 05). BothFas and FasL expression was not related to the histological type of lung cancer (P>0. 05). Thelevel of Fas expression was negatively related to that of FasL (P<0. 05). Conclusion:Down-regulation of Fas and up-regulation of FasL may work in coordination with the occurrence,development and metastasis of lung cancer. Fas or FasL can be used as one of markers in earlydiagnosis of lung cancer. Therefore, the combined assay may be helpful in predicting the grade ofmalignancy and the prognosis of patients with lung cancer.目的:研究肺癌组织中Fas和FasL表达及临床意义。方法:采用免疫组化SP法对46例肺癌组织和30例癌旁肺组织进行Fas和FasL表达检测。结果:在肺癌组织中,Fas表达下调,FasL表达明显上调。Fas在鳞癌、腺癌和小细胞肺癌中表达水平显著低于癌旁肺组织(P<0.01),且与肺癌的病理分级、临床分期及转移呈负相关(P<0.05)。分化程度低、已发生转移的肺癌Fas表达水平显著下调(P<0.05)。而FasL在鳞癌、腺癌和小细胞肺癌中表达水平显著高于癌旁肺组织(P<0.05),且与肺癌的病理分级、临床分期及转移呈正相关(P<0.05)。分化程度低、临床分期晚及已发生转移的肺癌FasL表达水平明显上调(P<0.05)。Fas和FasL表达水平间呈负相关(P<0.05)。结论:肿瘤通过下调Fas、上调FasL这种表达异常在肺癌发生、发展及转移过程中可能起协同作用。Fas和FasL可能成为早期诊断肺癌的标志物之一,联合检测对判断肺癌恶性程度及预测预后有较大参考价值。

关 键 词：FAS FASL lung cancer 

分 类 号：R734.2[医药卫生—肿瘤]