婴儿双歧杆菌黑色素瘤靶向性的探讨  

Investigation on tumor-targeting characteristics of bifidobacterium infantis to melanoma

作　　者：吴瑜[1] 张静 王树人[1] 

机构地区：[1]四川大学华西基础医学与法医学院病理生理教研室,成都610041

出　　处：《四川生理科学杂志》2003年第1期27-29,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的 :探讨婴儿双歧杆菌对黑色素瘤组织的靶向性。方法 :用3H TdR标记婴儿双歧杆菌 ,进行放射性体内参入示踪分析 ;组织切片革兰氏染色 ,进行图像分析。结果 :仅瘤组织内放射性强度随时间延长持续增强 ,且存在大量革兰氏染色阳性紫蓝色深染区。结论Objective: To investigate the tumor targeting of Bifidobacterium infantis to melanoma. Methods: After bolus administration of Bifidobacterium infantis with 3H TdR tagged,the radioactivity in tumor and organs were examined along with the time. Immunohistochemical analysis was also taken for examination of distribution of Bifidobacterium infantis in tissues. Results: Radioactivitis in melanoma tissue increased progressively, while the radioactivity in normal organs weakened as times goes on. A large part of area was Gram's positive found in tumor tissue only. Conclusion: Bifidobacterium infantis has tumor targeting characteristics in mice melanoma.

关 键 词：婴儿 双歧杆菌 黑色素瘤 靶向性 

分 类 号：R363[医药卫生—病理学]