垂体腺瘤患者的围手术期垂体激素监测及临床意义  

Perioperative comparative study on the pituitary hormone level in pituitary adenoma

作　　者：孔军[1] 王厚忠[1] 丰育功[1] 张兵[1] 吴唏[1] 

机构地区：[1]青岛市立医院,山东青岛266011

出　　处：《山东医药》2003年第15期3-5,共3页Shandong Medical Journal

摘　　要：为了对垂体腺瘤患者进行手术前后激素测定、分型、并监测术后垂体功能以及寻求一种判断手术切除程度及术后有无复发的方法 ,对 5 0例垂体腺瘤手术患者采用放免法测定手术前、后激素水平 ,对测定值进行回顾性分析 ,判断检测结果的相互关系并分析其临床意义。结果 :泌乳素 (PRL)腺瘤及生长激素 (GH)腺瘤全切组及未全切组术后激素水平均较术前明显降低 (P <0 0 5 ) ,全切组术后激素水平与未全切组比较有明显差异 (P<0 0 5 )。认为手术治疗可以明显改善垂体瘤患者术前高激素水平状态 ,手术治疗有着肯定的治疗价值。其切除程度将决定着术后内分泌的改善水平 。To make preoperative typing of pituitary hormone,postoperative examination of pituitary function and assessment of degrees of tumor removal and recurrence in pituitary adenuma,50 patients of pituitary adenuma were divided into two groups and their hormone levels were determined with radioimmunoassay.The result showed that the level of the pituitary hormone was significantly decreased after complete or incomplete tumor removal in PRL adenoma and GH adenoma,as compared with before operation(P<0.05).The postoperative level of the pituitary hormone was significantly lower in the complete tumor removal than in the group with incomplete tumour removal(P<0.05). This suggest that the operative treatment significantly lowers the high hormone level ,and has evident therapeutic value in pituitary andeoma.Pituitary adenoma should be excised as completely as possible on the prerequisite of not injuring the normal pituitary tissues.

关 键 词：垂体腺瘤 外科手术 围手术期 垂体激素 监测 临床意义 手术入路 

分 类 号：R736.4[医药卫生—肿瘤] R730.56[医药卫生—临床医学]