大鼠巨细胞网状核和中缝大核5-羟色胺神经元在痛觉调制中的作用  

PAIN-MODULATING ROLE OF SEROTONIN NEURON IN NUCLEUS RETICULARIS GIGANTOCELLULARIS AND NUCLEUS RAPHE MAGNUS IN THE RAT

作　　者：徐旭东[1] 李戬[1] 刘晓安[1] 屠建琪[1] 

机构地区：[1]济宁医学院神经解剖学研究室

出　　处：《济宁医学院学报》1992年第1期6-10,共5页Journal of Jining Medical University

摘　　要：本文采用特异性化学损毁技术及钾离子透入法测痛,观察了用5.6-双羟色胺(5.6—DHT)破坏了大鼠巨细胞网状核(NGC)和中缝大核(NRM)内5—羟色胺(5—HT)神经元后痛阈的变化。结果表明:NGC 内注射5.6—DHT 后,第4、6、8天痛阈较基础痛阈显著下降。NRM 内注射5.6—DHT 后,第4、6、8和16天痛阈较注射前均有显著下降,且痛阈下降幅度大,恢复过程长。提示:NGC 或NRM内5—HT 神经元均参与痛觉的下行调制,而NRM 内5—HT 神经元在镇痛中可能处于主要地位。本文并对NGC 和NRM 内5—HT 神经元在痛觉调制中的相互关系进行了分析。the modulating role of serotoniu(5—HT)neuron in nucleus reticul-aris gigantocellularis(NGC)and nucleus raphe magnus(NRM)was investigatedby selective chemical damage technique using 5,6—dihydroxytryptamine(5,5.6-DHT).The pain threshold was determined by potassium iontophoretic dolori-metry.The results showed that pain thresholds significantly decreased in theNGC expenimental group on the 4th,6 thanp 8th days after the injection andin the NRM experimental groud on the 4th,6th,8th and 16th days.The NRMexperimental group had the lowest threshold and a longer period of restoration.These experiments suggest that both NGC and NRM serotonergic systems areinvolved in the descending modulating nociceptive processes and the NRM serotonergicsystem appears to play a more important role in pain modulating.

关 键 词：巨细胞网状 中缝大核 血清素 

分 类 号：R324[医药卫生—人体解剖和组织胚胎学]