纤维蛋白单体聚合功能测定对脑梗死病情评价的临床研究  

Study of fibrin monomer polymerization function in patients with cerebral infarction

作　　者：洪梅[1] 魏文宁[1] 李红戈[2] 杨锐[1] 杨焰[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院血液病研究所,武汉430022 [2]华中科技大学同济医学院附属协和医院神经内科,武汉430022

出　　处：《卒中与神经疾病》2003年第3期169-171,共3页Stroke and Nervous Diseases

摘　　要：目的　研究脑梗死患者纤维蛋白单体聚合功能与梗死体积和神经功能缺损程度的关系 ,并探讨其临床意义。方法　将 82例脑梗死患者依据不同的梗死体积分为小梗死组、中梗死组和大梗死组 ;依据临床神经功能缺损程度评分标准 ,分为轻、中、重三型 ,检测患者纤维蛋白单体聚合功能参数 ,设立 5 0例健康人为对照组。结果　脑梗死患者纤维蛋白单体聚合功能各项参数均较健康人显著增高。不同梗死体积组中 ,大梗死组纤维蛋白单体聚合速率 (FMPV)较小梗死组和中梗死组显著增高 ;不同程度神经功能缺损组中 ,重度缺损组FMPV和分子功能参数较轻度缺损组显著增高 ,中度缺损组FMPV较轻度缺损组显著增高。脑梗死患者神经功能缺损程度评分与纤维蛋白聚合功能各项参数呈不同程度的正相关。结论　纤维蛋白单体聚合功能测定不仅能全面地反映纤维蛋白原 (Fbg)的质量状态 ,而且与脑梗死的病情密切相关 ,纤维蛋白单体聚合功能参数 ,特别是FMPV的增加可能反映病情严重程度 ,对患者病情的临床评价具有一定的意义。Objective To study the relations between fibrin monomer polymerization function and the volume of infarction and clinical evaluation in patients with cerebral infarction.Methods Fibrin monomer polymerization function was detected in 82 patients and 50 healthy control subjects.We grouped patients according to the volume of infarction and scores of clinical evaluation.Results The fibrin monomer polymerization function in patient group with cerebral infarction was significantly higher than control group.Patients with big size infarction had higher fibrin monomer polymerization velocity (FMPV) than patients with small and middle size infarction.FMPV and molecular function of fibrinogen (Fbg) in group with severe damage of nerve function were higher than mild damage group.FMPV in middle damage group was also higher than mild damage group.There was a positive correlation between fibrin monomer polymerization function and scores of clinical evaluation in different degree. Conclusions Fibrin monomer polymerization function could be highly related to cerebral infarction and contribute to clinical evaluation of patients.

关 键 词：纤维蛋白单体聚合功能 测定 脑梗死 病情 神经功能缺损 梗死体积 

分 类 号：R743.33[医药卫生—神经病学与精神病学]