脑康灵胶囊中挥发油的提取及β-环糊精包合工艺研究  

Extraction of Volatile Oil from Naokangling Capsule and Processing Techniques of Its p-cyclodextrin Inclusion Compound

作　　者：王岩[1] 周莉玲[1] 张牡丹[1] 王绮雯[1] 

机构地区：[1]广州中医药大学中药学院,广州510405

出　　处：《广州中医药大学学报》2003年第2期165-167,共3页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：[目的]研究中药制剂脑康灵胶囊中挥发油的提取及β-环糊精(β-CD)包合的最佳工艺。[方法]采用正交试验法,分别以挥发油的提取率及β-CD包合物的包合率、收得率为指标,对影响挥发油提取和包合效果的主要因素进行优选。[结果]挥发油的最佳提取工艺为药材加10倍量水,浸泡1h,蒸馏5h;包合物的最佳制备工艺为挥发油加6倍量β-CD,包合2h,包合温度为40℃。[结论]该工艺可提高制剂的稳定性,方法简便易行,可用于生产。[Objective] To screen an optimal method for the extraction of volatile oil from Naokangling Capsule (NC) and processing techniques of β-cyclodextrin (β-CD) inclusion compound of NC. [Methods] The study was carried out with orthogonal design . Oil-extraction ratio, oil-bearing rate and inclusion rate of β-CD inclusion compound of NC were used as indexes. [Results] The optimal process for oil extraction was adding 10-fold water in medicinal materials and then soaking for one hour and distilling for 5 hours. The optimal processing conditions for β-CD inclusion compound of NC were: the proportion of β-CD and volatile oil being 6:1, the inclusion compound being stirred for 2 hours at 40℃ . [Conclusion] This method is simple and practical and can increase the stability of preprations. It can be used for the production of β-CD inclusion compound in a large scale.

关 键 词：脑康灵胶囊 挥发油 提取 Β-环糊精 包合 最佳工艺 

分 类 号：R286[医药卫生—中药学]