维生素C生物转化的代谢工程研究  

Research progress in the metabolic engineering for the conversion of vitamin C by bacteria

作　　者：袁红杰[1] 张惟材[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2003年第3期245-248,共4页Letters in Biotechnology

摘　　要：本文从代谢工程角度出发,综述维生素C(Vc)生物转化代谢研究进展。分别论述了3条产生Vc重要前体2-酮基-L-古龙酸(2-KLG)反应路线的代谢机制、反应酶系及代谢工程菌构建等方面的问题;并对Vc生物转化应用前景作了展望。Base on the theory of metabolic engineering,the progress in the conversion of vitamin C by bacteria was reviewed.The metabolic mechanism,enzymes and the construction of the recombinant strains of producing2-keto-L-gluonic acid,an important precursor,in three metabolic pathway for the conversion of vitamin C were described.The future of this research area and possibility of application were discussed.

关 键 词：维生素C 生物转化 代谢工程 2-酮基-L-古龙酸 反应路线 代谢工程菌 

分 类 号：TQ924[轻工技术与工程—发酵工程]