5-氟尿嘧啶-1-乙酸锌单晶的合成、结构及抗菌活性研究  

Synthesis and Crystal Structure of 5-fluorouracil-1-acetic Acid Complex with Zn(Ⅱ) and Study for Bactericidal Activity

作　　者：宋之刚[1] 张伏龙[1] 

机构地区：[1]甘肃联合大学理工学院,甘肃兰州730000

出　　处：《甘肃教育学院学报（自然科学版）》2003年第3期32-36,共5页Journal of Gansu Education College(Natural Science Edition)

摘　　要：制备了5 氟尿嘧啶 1 乙酸锌单晶,并作了晶体结构分析.晶体数据:单斜晶系、空间群P21/C(#14),a=0.8571(2)nm,b=1.2102(2)nm,c=1.0814(2)nm,V=1.1213(7)nm3,β=91.53(2)°,Dcalc=1.729g·cm-3,Z=2.对三种细菌的抑菌实验表明配合物比配体有强抑菌活性.Crystal of 5fluorouracil1acetic Acid Complex with Zn(Ⅱ) has been prepared and characterized by an Xray crystal structure.Crystal date:monoclinic,space group P21/C(#14),a=0.8571(2)nm,b=1.2102(2)nm,c=1.0814(2)nm,V=1.1213(7)nm3,β=91.53°,Dc=1.729g·cm-3,Z=2.It has been found that both ligand and complex have an activity of inhibition against three bacteria strains.

关 键 词：5-氟尿嘧啶-1-乙酸锌 锌配合物 晶体结构 抑菌活性 抗癌药 

分 类 号：R979.1[医药卫生—药品] R914[医药卫生—药学]