西安酒精性肝病流行病学  

Epidemiology of alcoholic liver diseases in Xi'an

作　　者：鲁晓岚[1] 陶明[2] 罗金燕[1] 耿燕[3] 赵平[1] 赵红莉[1] 

机构地区：[1]西安交通大学第二医院消化病研究室,陕西省西安市710004 [2]西安交通大学医学院流行病学教研室,陕西省西安市710061 [3]西安交通大学第二医院检验科,陕西省西安市710004

出　　处：《世界华人消化杂志》2003年第6期719-722,共4页World Chinese Journal of Digestology

基　　金：卫生部科研基金;No.98-1-236

摘　　要：目的:酒精性肝病近年呈增长之势,世界各国对其越来越重视,本研究采用流行病学方法调查西安地区人群的饮酒情况,初步明确酒精性肝病的患病率及与饮酒的关系。方法:将西安城乡9种代表性职业人群作为本次调查对象,整群随机抽样,采取问卷调查方法,由专人统一询问检测结果:2000-04/06共调查9种职业人群3613例,其中饮酒人数1270例,占35.2％,90.1％为男性,是男性群体的52.2％,女性仅126例,检出酒精性肝病患者82例,占6.5％,为调查人数的2.3％,只1例女性,酒精性肝硬化4例,分别占0.3％和0.1％,78例酒精性脂肪肝患者日均饮酒31.3±24.2g,平均饮酒14.0±7.4a,且随饮酒量和饮酒时限增加,ALT和AST亦渐升高,发病高峰年龄在40岁左右,营养不良可能加重肝功能损伤。结论:西安地区饮酒现象较普遍,男性为主要饮酒人群,酒精性脂肪肝为酒精性肝病最常见类型,患病率2.2％,日均饮酒30g,持续14a即可能患此病,且与ALT、AST水平有正向关系。AIM: To investigate the characteristics of ethanol consumption in Xi'an area, and to explore the prevalence of alcoholic liver disease and the correlation of the quantity of ethanol consumed with the development of alcoholic liver disease. METHODS: By random cluster sampling, 9 professional groups of people were chosen in the city and the rural areas as subjects. Questionaire was taken and the data collected and analyzed by specialists.. RESULTS: During April to June 2000, 3 613 persons were investigated. Among them 1270 were drinkers, in which 90.1％ were males and only 126 females. 78 persons were alcoholic fatty liver patients (6.1％). The prevalence rate was 2.2％ in all subjects. Only one female patient with alcoholic liver disease (0.3％), and 5 cases of alcoholic cirrhosis (0.1％) were found. Alcoholic fatty liver patients consumed the equivalent of 31.3+24.2 g absolute ethanol with a mean duration of 14.0+7.4 years. With increase of alcoholic consumption the serum levels of ALT and AST increased. The prevalence rate of alcoholic fatty liver is higher in city than that in rural area. CONCLUSION: Alcohol drinkers in Xi'an are very popular. Males are the major population. Alcoholic fatty liver is the most common type of ALD with prevalence rate of 2.2％. The equivalent of 30g ethanol consumed in more than 14 years may result in alcoholic fatty liver. The alterations of liver function are parallel to the consumption of alcohol.

关 键 词：西安市 酒精性肝病 流行病学 调查 酒精性脂肪肝 饮酒 

分 类 号：R575[医药卫生—消化系统]