干燥法长期保存角膜片板层治疗性角膜移植1267例临床研究  

The Clinical Study of 1 267 Cases Therapeutic Keratoplasty Using Donor Corneal Grafts in Long-time Preservation with Dehydrated

作　　者：朱秀萍 张长宁 吴洁 马挺 朱斌良 刘景堂 银勇 刘先宁 杨问学 

机构地区：[1]西安市眼科医院西安市眼科研究所,西安710002

出　　处：《眼科学报》2003年第2期110-113,共4页Eye Science

摘　　要：目的:评价干燥脱水法长期保存角膜片在板层治疗性角膜移植术中的效果。方法:保存角膜片选自我院眼库干燥保存符合临床标准、复水透明的完整角膜片,临床病例选自我院角膜病组1976年8月～1999年12月期间行板层治疗性角膜移植患者1267例,从手术前后视力比较、原发病灶控制、植片存活情况进行临床效果综合分析。结果:保存角膜片复水透明合格率为94.9%,临床治愈率:感染性角膜溃疡/穿孔88.8%,血管翳性全角膜白斑98.3%,化学及热烧伤(穿孔,睑球角粘连等)92.1%,圆锥角膜及急性圆锥角膜99.5%,角膜变性(边缘性及前基质层)99.0%,其他88.9%,平均总治愈率:93.5%。结论:1.对各种严重的角膜感染、药物治疗无法控制的病人,治疗性角膜移植术是唯一有效的方法。2.采用无水氯化钙——硅胶干燥脱水长期保存的供体角膜能为临床随时提供角膜材料,是一项简单易行、便于推广应用的成功率很高的保存方法。眼科学报2003;19:110-113。Purpose:To evaluate its effects of 1 267 cases therapeutic keratoplasty using donor corneal grafts in long-time preservation with dehydrated. Methods:The long-time preservated donor corneal grafts came from Xi'an Eye Bank, they accorded with the clinical demands. To select 1 267 cases therapeutic keratoplasty in August 1976 to December 1999,and make an analysis of preoperation and post-operation visual contrast, original focus controlling, donor corneal grafts reviviscence. Result:The transparent rate of donor corneal grafts after presevation was 94.9%, the clinical cure rate: Infective corneal ulcer/perforation 88.8% , pannus totalis and corneal opacity 98.3% , chemical burn and heat burn (perforation corneoblepharon) 92.1%,keratoconus and acute keratoconus 99.5%, corneal degeneration (marginal shallow of stroma) 99.0%,other cases 88.9%, mean all effective rate 93.5%. Conclusion: 1.For the treatment of serious corneal infection,and cases which poorly respond to medicine, therapeutic keratoplasty may be the only effective method. 2.Longtime corneal dehydration in water-free calcium chloride-silica gel may provide clinical supply of corneal materials whenever necessary, so it is an easy and simple, highly applicable method. Eye Science 2003;19:110-113.

关 键 词：保存 角膜片 板层角膜移植 干燥脱水法 手术指征 术后发并症 

分 类 号：R779.65[医药卫生—眼科]