先倍领对大鼠微循环和血液流变学的影响  

The effects of hemorheology and microcirculation on rat model of blood stasis syndrome on the xianbeiling

作　　者：唐荔[1] 石小鹏[1] 郭凤伟[1] 沈敏[1] 戴甜甜[1] 

机构地区：[1]第四军医大学西京医院药剂科,陕西西安710032

出　　处：《心脏杂志》2003年第3期233-235,共3页Chinese Heart Journal

摘　　要：目的 :观察先倍领对血瘀大鼠微循环和血液流变学特性的影响。方法 :SD大鼠 3 0只 ,随机分为空白组、模型组和实验组 ,在连续 14 d中 ,实验组大鼠肌注先倍领注射液 ( 0 .2 5 ml· kg-1 ) ,在第 13天 ,将实验组和模型组大鼠皮下注射肾上腺素 ( 0 .0 7ml· kg-1 )和冰水刺激造成大鼠急性血瘀模型 ,观察大鼠肠系膜微循环及血液流变学指标 ;空白组和模型组给予同样体积的生理盐水。结果 :先倍领与模型组相比 ,在微循环各指标中均存在显著性差异( P<0 .0 1) ,在血液流变学各指标中也存在显著性差异 ( P<0 .0 5或 P<0 .0 1)。结论AIM: To observe the effects of hemorheology and microcirculation on rat model of blood stasis syndrome on the xianbeiling . METHODS: In the 14 days ,The rat was administered continuously the xianbeiling by im (0.25 ml·kg -1 ). At the 13 d, the rat of both the experiment group and model group were made the model of blood stasis syndrome by ip adrenalin (0.07 ml·kg -1 ) and the stimulation of ice water,to observe the microcirculation of mesentery and determine the index of hemorheology; the same bulk of NS was administered in controll, the same bulk of PASS was iv in model. RESULTS: Comparing the model, the xianbeiling can markedly improve the index of the hemorheology and microcirculation ( P <0.05 or P <0.01). CONCLUSION: The xianbeiling has the ability of improvement on the rat of blood stasis syndrome.

关 键 词：先倍领注射液 流变学特性 微循环 血瘀症 

分 类 号：R912[医药卫生—药学]