脑性瘫痪儿童垂体-肾上腺皮质轴系统功能的检测  

The function of hypophysis-adrenal cortex axis in children with cerebral palsy

作　　者：李永库 王松柏 李树春 董广英[2] 

机构地区：[1]小儿神经精神病研究所 [2]佳木斯永红区医院

出　　处：《佳木斯医学院学报》1992年第5期35-37,共3页

摘　　要：脑性瘫痪是出生前到出生后1个月内发育时期的非进行性脑损伤所致综合征,主要表现为中枢性运动障碍及姿势异常。本病发病率国外为1‰—2‰,国内为1.8‰—4‰。国外有资料表明,本病患儿垂体—肾上腺皮质轴系统功能偏低。其血中ACTH及Cortisol水平低,在一定程度上反映了中枢神经系统,特别是下丘脑的损害。但其检测方法为生化学方法检测激素的代谢产物。国内尚无这方面的报导。我们采用放免法检测患儿血中ACTH及Cortisol的含量,以探索脑性瘫痪儿童垂体—肾上腺皮质轴系统功能的改变及其程度,并提高了检测的灵敏度及准确性。The levels of serum ACTH and cortisol were measured in 40 patients with cerebral palsy (7--50 months of age)and 35 healthy children (4--50 months of age)by RIA method. The results showed that levels of serum ACTH (7. 98pg/ml)and cortisol (7. 61μg/dl) in patients with cerebral palsy were significant lower, compared with healthy children (respectively 18. 89pg/ml, and 20. 00μg/dl). The levels of serum ACTH in mild and moderate patients with cerebral palsy (11. 45pg/ml, 11. 55pg/ml)were significant lower, compared with severe type of the patients. The difference of serum cortisol between mild, moderate and severe type of the patients was significant (11. 91μg/dl, 8. 47μg/dl and 2. 41μg/dl). The levels of seruin ACTH (6. 02pg/ml) and cortisol (4. 97μg/dl) in Athetosis cerebral palsy were significantly lower, compared with spastic cerebral palsy (9. 56μg/ml, 9. 52μg/dl). The function of hypophysis -- adrenal cortex axis in patients with cerebral palsy was proved to lower, compared with healthy children and was obviously lower in Athetosis.

关 键 词：脑性 瘫痪 垂体 肾上腺皮质 ACTH 

分 类 号：R742.304[医药卫生—神经病学与精神病学]