大肠腺癌p53和表皮生长因子受体的表达及其意义  

Expressions and clinical significances of p53 and epidermal growth factor receptor in colorectal adenocarcinoma

作　　者：罗志谋[1] 蔡沛然[1] 洪亮[1] 

机构地区：[1]上海瑞金医院集团闵行医院病理科,201100

出　　处：《上海医学》2003年第6期315-317,T003,共4页Shanghai Medical Journal

摘　　要：目的　探讨p5 3与表皮生长因子受体 (EGFR)蛋白在大肠腺癌中的表达及其意义。方法　采用免疫组织化学单克隆抗体Envision方法 ,检测 166例大肠腺癌、5 5例大肠腺瘤和 2 0例大肠增生性黏膜组织中 p5 3及EGFR蛋白的表达水平。结果　p5 3和EGFR的阳性细胞表达率由增生性黏膜、腺瘤至腺癌依次递增 ,分别为 10 .0 %、3 6.4%、63 .0 %和 40 .0 %、5 5 .0 %、75 .3 % ,各组比较 ,差异均有显著性 (P <0 .0 1)。p5 3和EGFR均与大肠癌的分化程度、淋巴结转移和分期有关。结论　p5 3和EGFR蛋白表达率与大肠癌的分化程度、分期、浸润及转移均密切相关 ,此Objective To observe the expressions and clinical significances of p53 and epidermal growth factor receptor (EGFR) in colon adenocarcinoma. Methods The espressions of p53 and EGFR were evaluated with immunohistolchemcal method in 166 Cases with Colon adenocarcinoma, including 55 colonic adenomas and 20 hyperplastic colonic mucosa. Results For colon adenocarcinoma, colon adenoma and hyperplastic colonic mucosa; the positive rates of expressions of p53 and EGFR were 10.0% , 36.4%; 63.0%, 40.0%; and 55.0% and 75.3%, respectively. There were statistical differences between the three groups. The positive rates of p53 and EGFR were related to the degree of differenciation, metastasis of lymph nodes and staging in colon adenocarcinoma. Conclusion The expressions of p53 and EGFR can figure out evaluation of the malignant degree and predict the prognosis of colon adenoma and carcinoma.

关 键 词：大肠腺癌 P53 表皮生长因子受体 免疫组织化学 抑癌基因 单克隆抗体 

分 类 号：R735.34[医药卫生—肿瘤]