Synthesis of Chlorin-enediyne Dyads by Palladium-catalyzed Coupling Reaction  

作　　者：王进军 韩光范 殷军港 邬旭然 赵岩 宫宝安 沈荣基 

机构地区：[1]Department of Applied Chemistry, Yantain University, Yantai, Shandong 264005, China [2]School of Material Science and Engineering, East China Shipbuilding Institute, Zhenjiang, Jiangsu 212003, China [3]Bioorganic Science Division, Korea Research Institute of Technology, 100 Jang Dong, Yusong Gu, Taejon 305 600, Korea

出　　处：《Chinese Journal of Chemistry》2003年第6期674-679,共6页中国化学（英文版）

基　　金：ProjectsupportedbytheMinistryoftheScienceandTechnologyofChinaasacooperativeProjectbetweenChinaandKorea ( 2 0 0 2 )

摘　　要：Methyl 9 ethylenedioxpyropheophorbide d was prepared from methyl pyropheophorbide a by protection of cyclic ketone with ethylene glycol, and oxidation with OsO 4 in vinyl group at 2 position. The terminal alkyne was introduced into chlorin chromophore by Grignard reaction, and the enediyne moiety was constructed by a palladium catalyzed coupling reaction with (Z) chloroenynes.Methyl 9 ethylenedioxpyropheophorbide d was prepared from methyl pyropheophorbide a by protection of cyclic ketone with ethylene glycol, and oxidation with OsO 4 in vinyl group at 2 position. The terminal alkyne was introduced into chlorin chromophore by Grignard reaction, and the enediyne moiety was constructed by a palladium catalyzed coupling reaction with (Z) chloroenynes.

关 键 词：ENEDIYNE CHLORIN chlorin  enediyne dyads photodynamic therapy anticancer agent 

分 类 号：O621.25[理学—有机化学]