ENEDIYNE

作品数：8被引量：17H指数：2
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Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus被引量：1
《CCS Chemistry》2024年第2期487-496,共10页Ke Sun Zhe Ding Xiaoying Jia Haonan Cheng Yingwen Li Yan Wu Zhuoyu Li Xiaohua Huang Fangxu Pu Entao Li Guiyou Wang Wei Wang Yun Ding Gary Wong Sandra Chiu Jiaming Lan Aiguo Hu 
the National Natural Science Foundation of China(grant no.21871080);the Eastern Scholar Professorship(for A.H.);the Natural Science Foundation of Shanghai(grant no.20ZR1463900)(for J.L.).
The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses worldwide.Unfortunately,state-of...
关键词：ENEDIYNE broad spectrum antiviral protein disintegration coronavirus POLYANIONS 
Palladium-catalyzed Cycloaromatization Polymerization of Enediynes
《Chinese Journal of Polymer Science》2018年第2期237-243,共7页Chonggang Wang Shudan Chen Hao Zhou Jinlou Gu Aiguo Hu 
financially supported by the National Natural Science Foundation of China (No. 21474027);Shanghai Leading Academic Discipline Project (No. B502);the "Eastern Scholar Professorship" support from Shanghai local government
Bergman cyclization has shown great promise in constructing conjugated polymers. However, the application of this reaction in polymer science is still limited due to the harsh reaction condition and ill-defined struct...
关键词：Transition metal catalysis ENEDIYNE POLYMERIZATION CYCLOAROMATIZATION Bergman cyclization 
Synthesis of Chiral Polyphenylenes through Bergman Cyclization of Enediynes with Pendant Chiral Amino Ester Groups被引量：1
《Chinese Journal of Polymer Science》2015年第5期743-753,共11页Shiyuan Sun Binlei Huang Fei Li Depeng Song 胡爱国 
financially supported by the National Natural Science Foundation of China(Nos.21474027,91023008);Ph.D.Programs Foundation of Ministry of Education of China(No.20100074110002);the Fundamental Research Funds for the Central Universities,and Shanghai Leading Academic Discipline Project(No.B502)
Chiral enediynes with pendant chiral amino ester groups are synthesized through Sonogashira reactions and subjected to thermal triggered Bergman cyclization at elevated temperatures either in bulk or in solvents to pr...
关键词：Enediyne Bergman cyclization Chiral polyphenylene MALDI-TOF/MS 
Site-specific PEGylation of lidamycin and its antitumor activity被引量：2
《Acta Pharmaceutica Sinica B》2015年第3期264-269,共6页Liang Li Boyang Shang Lei Hu Rongguang Shao Yongsu Zhen 
supported by the National Science and Technology Major Project for Major New Drug Innovation (Nos.2013ZX09102064 and 2014ZX09201042-003)
In this study,N-terminal site-specific mono-PEGylation of the recombinant lidamycin apoprotein(r LDP) of lidamycin(LDM) was prepared using a polyethyleneglycol(PEG) derivative(Mw20 k Da) through a reactive terminal al...
关键词：Enediyne antibiotic Polyethylene glycol Site-specific PEGylation LIDAMYCIN 
Synthesis of Polyphenylenes through Bergman Cyclization of Enediynes with Long Chain Alkyl Groups被引量：2
《Chinese Journal of Polymer Science》2015年第1期184-191,共8页Shiyuan Sun Luhua Dong Depeng Song Binlei Huang 胡爱国 
financially supported by the National Natural Science Foundation of China(Nos.20874026 and 91023008);Ph.D.Programs Foundation of Ministry of Education of China(20100074110002);the Fundamental Research Funds for the Central Universities,Shanghai Leading Academic Discipline Project(B502);AH thanks the"Eastern Scholar Professorship"support from Shanghai local government
Several new enediynes with long chain alkyl groups were synthesized through Sonogashira coupling reactions between long chain alkynes and（Z）-1,2-dichloroethene. These enediynes（1） were then subjected to thermal Be...
关键词：Enediyne Bergman cyclization Polyphenylene. 
Molecular dynamics simulations investigation of Neocarzinostatin Chromophore releasing pathways from the Holo-NCS protein
《生物物理学报》2009年第S1期377-377,共1页Xi Zhao1, Song Wang1, Xue-feng Gao2, Xu-ri Huang1, Chia-chung Sun1 1 State Key Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, Jilin University, Changchun 130023, People’s Republic of China 2 College of L ife Science,Jilin University, Changchun 130023, People’s Republic of China 
The enediyne ring chromophore with strong DNA cleavage activity of neocarzinostatin is labile and therefore stabilization by forming the complex (carrying protein + chromophore:
关键词：Neocarzinostatin ENEDIYNE ring CHROMOPHORE release MOLECULAR DYNAMICS force-probe MOLECULAR DYNAMICS essential dynamics. 
Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication被引量：12
《World Journal of Gastroenterology》2004年第18期2632-2636,共5页Yue-XinLiang WeiZhang Dian-DongLi Hui-TuLiu PingGao Yi-NaSun Rong-GuangShao 
Supported by Grants from the Major State Basic Research Development Program Foundation of China,No.G2000057010 and G 1999053901 and Grants from the National Natural Science Foundation of China,No.30271438 and 30300424 and Grant from the Key Laborator
AIM: Mitotic cell death has been focused on in tumor therapy.However, the precise mechanisms underlying it remain unclear. We have reported previously that enediyne antibiotic lidamycin induces mitotic cell death at l...
关键词：细胞分裂 细胞凋亡 致死原因 BEL-7402细胞 抗生素 中心体 肝细胞癌 肿瘤 
Synthesis of Chlorin-enediyne Dyads by Palladium-catalyzed Coupling Reaction
《Chinese Journal of Chemistry》2003年第6期674-679,共6页王进军 韩光范 殷军港 邬旭然 赵岩 宫宝安 沈荣基 
ProjectsupportedbytheMinistryoftheScienceandTechnologyofChinaasacooperativeProjectbetweenChinaandKorea ( 2 0 0 2 )
Methyl 9 ethylenedioxpyropheophorbide d was prepared from methyl pyropheophorbide a by protection of cyclic ketone with ethylene glycol, and oxidation with OsO 4 in vinyl group at 2 position. The terminal alky...
关键词：ENEDIYNE CHLORIN chlorin  enediyne dyads photodynamic therapy anticancer agent 
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