多发性硬化患者趋化因子MCP-1的表达及意义  

MCP - 1 in multiple sclerosis patients and its significance

作　　者：范立红[1] 丁美萍[2] 

机构地区：[1]浙江杭州市红十字会医院神经内科,杭州310003 [2]浙江大学医学院附属第二医院神经内科,杭州310009

出　　处：《河南实用神经疾病杂志》2003年第3期14-16,共3页Henan Journal of Practical Nervous Diseases

摘　　要：目的 测定急性期多发性硬化(MS)患者血清及脑脊液中的趋化因子MCP-1的浓度变化,并对其结果作初步探讨。方法 用ELISA法检测20例急性期MS患者,20例其他神经系统疾患的血清/脑脊液中的趋化因子MCP-1的浓度。结果 急性期MS患者血清及脑脊液中的趋化因子MCP-1的浓度与对照组相比均下降。结论 急性期MS患者血清及脑脊液中的趋化因子MCP-1的浓度下降可能与T细胞的不同反应性有关,趋化因子可能参与MS的发病过程。Objective To study the chemokine expression in serum and CSF of patients with acute multiple sclerosis.Methods The serum and cerebrospinal fluid (CSF) levels of MCP- 1 were measured in 20 patients with Multiple Sclerosis (MS groups) and 20 patients with other neurological diseases (OND) by ELJSA. Results MCP- 1 concentration in serum and CSF from acute MS patients was diminished compared to controls. Conclusion MCP - 1 decreased may be related to the regulation of TH1/TH2 lymphocyte differentiation, chemokine was thought to be implicate in the immunopathogenesis of MS.

关 键 词：多发性硬化 趋化因子 MCP—1 ELISA 检测 血清 脑脊液 T细胞 

分 类 号：R744.51[医药卫生—神经病学与精神病学]