白介素1受体拮抗剂对兔实验性增生性玻璃体视网膜病变的抑制作用  

Prevention of experimental proliferative vitreoretinopathy of rabbits with IL-1Ra

作　　者：宋宗明[1] 沈丽君[1] 付小莹[1] 刘晓强[1] 瞿佳[1] 惠延年[2] 

机构地区：[1]温州医学院附属眼视光医院,浙江温州325003 [2]第四军医大学西京医院眼科,陕西西安710032

出　　处：《眼视光学杂志》2003年第2期82-85,共4页Chinese Journal of Optometry & Ophthalmology

基　　金：国家自然科学基金 ( 3 9970 780 );浙江省医药卫生科学基金( 2 0 0 2A0 67);浙江省教育厅科研基金 ( 2 0 0 2 0 463 )资助项目

摘　　要：目的 :评价白细胞介素 1受体拮抗剂 (IL 1recep toranti gonist,IL 1Ra)对实验性增生性玻璃体视网膜病变(proliferativevitreoretinopathy ,PVR)的抑制作用。方法 :32只兔眼分为对照组、IL 1Ra组、地塞米松组和联合用药组 (每组 8眼 ) ,将 2 .5× 10 5个视网膜色素上皮细胞 (retinalpigmentep ithelium ,RPE)注入玻璃体腔内建立PVR模型 ,各组分别给予IL 1Ra和地塞米松并联合用药 ,观察PVR的形成 ,计算各组PVR的发生率。结果 :第 4周末对照组 10 0 %发生视网膜脱离 ,IL 1Ra组 6 2 .5 %发生视网膜脱离 ,地塞米松组有 5 0 .0 %发生视网膜脱离 ,而联合用药组 2 5 .0 %发生牵拉性视网膜脱离。联合用药组比所有其他组的视网膜玻璃体病变轻 ,视网膜脱离的面积也较小。结论 :IL 1Ra可以降低兔实验性PVR的发生率 ,IL 1Ra与地塞米松联合应用能够增加地塞米松的作用效果。Objective:To investigate the effects of interleukin 1 receptor antigonist(IL 1Ra) on prevention of proliferative vitreoretinopathy(PVR).Methods:Sixteen rabbit(32 eyes) were divided into control,IL 1Ra,dexamethasone,and combined group,4 animals in each. Cultured human RPE cells(2.5×10 5) were injected into rabbits vitreous cavity to establish PVR model. Normal saline(0.1 ml),IL 1Ra(100 ng),dexamethasone(1 mg),IL 1Ra and dexamethasone(combined drugs) were injected into vitreous cavity respectively. Prevalence of PVR and retinal detachment were observed by direct ophthalmoscopy,B scan ultrasonography and pathology study.Results:Retinal detachment occurred 100%,62.5%,50% and 25% in eyes treated with the controls,IL 1Ra,dexamethasone group and combined drugs,respectively. Light microscopy showed the prevalence of traction retinal detachment(TRD) was in accord with indirect ophthalmoscopy and autopsy examination.Conclusion:IL 1Ra reduce the prevalence of PVR in rabbits;IL 1Ra enhances dexamethasone's inhibition effect.[

关 键 词：增生性玻璃体视网膜病变 白细胞介素1受体拮抗剂 地塞米松 联合用药 治疗 

分 类 号：R774.13[医药卫生—眼科] R977[医药卫生—临床医学]