重组人粒细胞-集落刺激因子对肺癌化疗患者中性粒细胞黏附功能的影响  

Effect of rhG - CSF on Expression of CD 18 and CD54 on Neutrophils in Chemotherapy Patients with Lung Cancer

作　　者：邢国宏[1] 张进川[1] 孙哓明[2] 

机构地区：[1]解放军总医院南楼呼吸科,北京100853 [2]济南军区总医院流式细胞室,济南250031

出　　处：《中国临床医学》2003年第3期362-363,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:以CD18、CD54为指标,观察rhG—CSF对肺癌化疗患者外周血中性粒细胞黏附功能的影响。方法:用流式细胞技术测定了12例肺癌化疗病人用rhG—CSF治疗前后的中性粒细胞表面CD18、CD54表达变化;对照组为接受化疗但未用rhG—CSF治疗的10例肺癌患者。结果:治疗组用rhG—CSF治疗前中性粒细胞表面CD18、CD54表达分别为:5.8％±2.7％、5.6％±2.6％,用rhG—CSF治疗后分别为11.3％±3.5％、14.2％±4.1％,治疗后显著升高(P<0.001);对照组化疗前后中性粒细胞表面CD18、CD54表达无差异。结论:rhG—CSF可增强外周血中性粒细胞表面CD18、CD54表达,影响中性粒细胞的黏附功能。Objective: To investigate the effect of recombinant human granulocyte - colony stimulating factor (rhG - CSF) on adherent function of peripheral neutrophil in chemotherapy patients with lung cancer. Methods; The expression of CD18 and CD54 on membrane of peripheral neutrophils were detected by flow cytometry in 12 chemotheraeutical patients with lung cancer before and after treatment with rhG -CSF. 10 lung cancer patients, without administration of rhG-CSF, were mea-sured the same parameters before and after chemotherapy as control group. Results: The expression percentages of CD18 (5. 8% ±2.7%) and CD54 (5.6%±2. 6% ) on membrane of peripheral neutrophils before treatment were significantly lower than thoseof CD18(11.3% ±3.5%)and CD54(14.2% ± 4.1%) after rhG - CSF treatment, respectively(P<0. 001). In control group, the changes of CD18 and CD54 were not signif icant. Conclusion: rhG -CSF can enhance expression of CD18 and CD54 on membrane of peripheral neutrophils and improve the adherent power of neutrophil.

关 键 词：重组人粒细胞-集落刺激因子 肺癌 化疗 中性粒细胞 黏附功能 影响 

分 类 号：R734.2[医药卫生—肿瘤]