胃肠起搏器治疗胃动力紊乱性疾病  

Gastrointestinal pacemaking for gastric dynamic disorders

作　　者：胡春燕[1] 厉有名[1] 刘有恃[1] 王杭勇[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2003年第3期249-252,共4页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的 :评价胃肠起搏器治疗胃动力紊乱性疾病的有效性和安全性。方法 :胃肠起搏器治疗 30例胃动力紊乱性疾病患者 (治疗组 ) ,并与胃肠起搏空白输出机治疗组及普瑞博思治疗组对照比较。治疗前后检查胃电图 ,记录胃电频率、幅值 ,观察临床症状。结果 :治疗组、空白组、普瑞博思组的临床症状总有效率分别为 90 .0 %、4 6 .6 %、86 .7% ,治疗组和普瑞博思组的治疗前后症状积分比较差别有显著性 (P<0 .0 5 ) ;治疗组治疗后胃电图空腹、餐后平均频率较治疗前明显改善 (P<0 .0 5 ) ,趋向正常频率 ;普瑞博思组仅治疗后餐后胃电平均频率较治疗前有改善(P<0 .0 5 ) ,空白组胃电频率治疗前后差异无统计学意义。结论 :胃肠起搏器治疗胃动力紊乱性疾病可改善临床症状及胃电生理的频率。Objective: To investigate the efficacy and safety of gastrointestinal pacemaker in treatment of gastric dynamic disorders.Methods:Sixty patients with more than two symptoms as postprandial fullness,epigastric pain,epigastric fullness,belch,nausea,hypercoria,anorexia,vomiting and at least for twelve weeks were divided into three groups randomly.Thirty patients were treated with gastrointestinal pacemaker for ten days(pace maker group);fifteen patients were treated with gastrointestinal placebo machine for ten days (control group);fifteen patients received treatment with cisapride 5 mg three times daily,thirty minutes before meal (cisapride group) for ten days.Electrogastrogram(EGG) was performed on before and after treatments,the mean frequency and mean amplitude of EGG,the clinical symptoms and adverse reactions were observed.Results:Total efficacy of pace maker group,control group and cisapride group was 90.0%,46.6% and 86.7%, respectively.The score of symptoms was significantly decreased after treatment with gastrointestinal pacemaker and cisapride (P<0.05).Before and after meal EGG exam showed that average frequency was reversed to normal level after treatment with gastrointestinal pacemaker.Conclusion:Gastrointestinal pacemaking can relieve symptoms and improve the average frequency of EGG in patients with gastric dynamic disorders.

关 键 词：胃动力紊乱性疾病 胃肠起博器 治疗 安全性 疗效 胃电图 

分 类 号：R573.9[医药卫生—消化系统]