脑适应性再灌注的实验研究  

The experimental study of cerebral adapted reperfusion

作　　者：邱永明 陆兆丰 陆兆辉 周洪语 董斌 罗其中 王祥瑞[2] 

机构地区：[1]上海市第二医科大学附属仁济医院神经外科,200001 [2]上海市第二医科大学附属仁济医院麻醉科

出　　处：《中国康复医学杂志》2003年第6期330-333,共4页Chinese Journal of Rehabilitation Medicine

基　　金：由国家自然科学基金资助(编号39900153)

摘　　要：目的:恢复缺血脑组织的灌注,是减轻缺血性损伤的根本方法。而如何恢复有效灌注,最大限度地减轻再灌注损伤则是治疗的关键所在。本文研究一种全新的脑缺血再灌注疗法———适应性再灌注。方法:24只蒙古犬随机分为四组:对照组、常规再灌注组、血液稀释组、适应性再灌注组。对犬的血气、血清离子浓度、血流动力学及电生理进行实时同步监测、分析,并对缺血脑组织学变化及神经功能进行评价。结果:脑适应性再灌注对血流的冲击小,对电解质的影响小,能明显改善再灌注区的损伤神经元的功能及病理。结论:脑适应性再灌注是一种具有神经保护作用的灌注方式,值得深入研究。Objective:Timely restoration of the perfusion of the ischemic cerebral tissue remains the cornerstone for the attenuation of ischmia/reperfusion injury.Furthermore,the key to attenuate the injury to the greatest extent is how to restore the more effective reperfusion.A kind of newly reperfusion in cerebrum,named cerebral adapted reperfusion(CAR)was studied.Method:Twenty-four mongrel dogs of either sex,weighing10-15kg,were randomly divided into four groups:the control group(Ctrl),the routine reperfusion group(Rout),the hemodilution group(Hemo)and the adapted reperfusion group(Adap).Basic vital signs,blood gas,[K + ],hemodynamics and electrophysiological changes were monitored and analysed.The cerebral ischemic histology and neurological function were evaluated.Result:The CAR has less impact on blood flow and[K + ],it was able to improve the function of ischemic neurons and its histological injury.Conclusion:The CAR is a beneficial reperfusion style have the neuroprotective effect.Its mechanism of neuroprotection is worthiness.

关 键 词：脑适应性再灌注 实验研究 脑缺血 治疗 血流动力学 

分 类 号：R741[医药卫生—神经病学与精神病学]