1-苯基-3-甲基-4-三氟乙酰基-5-吡唑啉酮缩水杨酰肼席夫碱的合成、表征及抑菌活性  

Synthesis, Characterization and Bacteriostatic Activity of Compound Derived from PMTFP and Salicylic Hydrazide

作　　者：张姝明[1] 贾永金[1] 王瑾玲[1] 缪方明[1] 

机构地区：[1]天津师范大学化学与生命科学学院,天津300074

出　　处：《天津师范大学学报（自然科学版）》2003年第2期4-6,共3页Journal of Tianjin Normal University：Natural Science Edition

基　　金：天津市自然科学基金资助项目(003601711)

摘　　要：合成了1-苯基-3-甲基-4-三氟乙酰基-5-吡唑啉酮缩水杨酰肼席夫碱,并对其进行了结构表征,预测其可能是一类很好的三齿配体.活性测定结果表明,此配体对革兰氏阳性-金黄色葡萄球菌和革兰氏阴性-大肠杆菌均有较强的抑制作用.A new compound derived from 1phenyl3methyl4trifluoroacetylpyrazolone5 and salicylic compoud hydrazide have been synthesized and characterized by IR and UV. The results show that the new compound may be a neutrals tridentate ligand and its bacteriostatic activity measured by paper disc method have good inhibiting functions for both Grampositive bacteria-Staphylococcus aureus  and Gramnegative bacteria-Escherichia coli, which provides scientific basis for determining the biological activities of its complexes.

关 键 词：1-苯基-3-甲基-4-三氟乙酰基-5-吡唑啉酮缩水杨酰肼席夫碱 合成 结构表征 抑菌活性 

分 类 号：O625.632[理学—有机化学]