肝脏缺血再灌注损伤与细胞凋亡  

Apoptosis and its modulation in hepatic ischemia and reperfusion injury

作　　者：马毅[1] 何晓顺[1] 陈规划[1] 

机构地区：[1]中山大学附属第一医院器官移植中心,广东广州510080

出　　处：《中国病理生理杂志》2003年第7期1005-1008,共4页Chinese Journal of Pathophysiology

基　　金：卫生部临床学科重点项目 (No .970 4 0 2 30 );广东省科委攻关基金 (No .99M0 4 90 2G)

摘　　要：Hepatic ischemia/reperfusion injury (HIRI) exists in lots of process of clinical pathology and operation. Apoptosis is an active process controlled by some gene and factors such as Fas/FasL, Caspases and Bcl-2 families. More and more studies suggest that HIRI is associated with apoptosis. This article summarized the mechanisms and gene modulation of apoptosis during HIRI and the significance of suppressing apoptosis in preventing HIRI.Hepatic ischemia/reperfusion injury (HIRI) exists in lots of process of clinical pathology and operation. Apoptosis is an active process controlled by some gene and factors such as Fas/FasL, Caspases and Bcl-2 families. More and more studies suggest that HIRI is associated with apoptosis. This article summarized the mechanisms and gene modulation of apoptosis during HIRI and the significance of suppressing apoptosis in preventing HIRI.

关 键 词：细胞凋亡 再灌注损伤 基因 肝 

分 类 号：R363[医药卫生—病理学]