甘氨酸对脂多糖诱导LBP mRNA表达的影响  

Influence of glycine on LBP mRNA expression induced by LPS in the liver of rats

作　　者：单于[1] 陆大祥[1] 王华东[1] 戚仁斌[1] 付咏梅[1] 李晓娟[1] 李楚杰[1] 

机构地区：[1]暨南大学医学院病理生理学教研室,广东广州510632

出　　处：《中国病理生理杂志》2003年第7期920-922,共3页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No .39870 36 0 );广东省自然科学基金项目资助项目 (No.980 70 6 )

摘　　要：目的 :了解甘氨酸 (GLY)对脂多糖 (LPS)诱导脂多糖结合蛋白 (LBP)mRNA表达的影响。方法 :用RT-PCR方法检测LPS作用下大鼠肝组织LBPmRNA的表达水平 ,并在此基础上观察甘氨酸对LPS诱导大鼠肝组织LBPmRNA表达的影响。结果 :LPS组大鼠肝组织LBPmRNA表达高于control组 (P <0 .0 1) ,GLY +LPS组大鼠肝组织LBPmRNA表达低于LPS组 (P <0 .0 1)。结论 :LPS可诱导大鼠肝组织LBPmRNA的表达 。AIM: To study the influence of glycine(GLY) on lipopolysaccharide-binding protein(LBP) mRNA expression induced by LPS. METHODS: The level of LBP mRNA expression in liver tissues of rats was examined by RT-PCR,and the effects of glycine on LBP mRNA expression in liver tissues of rats induced by LPS were investigated. RESULTS: The level of LBP mRNA expression in hepatic tissue of rats in the LPS group was significantly higher than that in the control group( P< 0.01),the level of LBP mRNA expression in the hepatic tissue of rats in the LPS+GLY group was lower than that in the LPS group( P< 0.01). CONCLUSION: LPS can induce LBP mRNA expression in the hepatic tissue of rats, glycine can inhibit LBP mRNA expression in the hepatic tissue of rats treated by LPS.

关 键 词：甘氨酸 脂多糖类 脂多糖结合蛋白 

分 类 号：R363[医药卫生—病理学]