肝细胞癌抗原Ki-67表达与肝亚段动脉栓塞疗效的相关性  

Relationship between the efficacy of subsegmental TACE and Ki-67LI of biopsy samples of HCCs

作　　者：李玉亮[1] 赵斌[1] 孙尧[1] 王永康[1] 李艳[1] 刘斌[1] 王振亭[1] 崔允峰[1] 

机构地区：[1]山东大学第二医院

出　　处：《山东大学学报（医学版）》2003年第3期318-321,共4页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨肝细胞癌抗原Ki-67(Kiel67antigen,Ki-67)表达水平与肝动脉化学栓塞疗效的关系。方法:以鼠抗人Ki-67单克隆抗体,应用免疫组化法检测31例肝细胞癌肝穿刺癌组织活检标本中的Ki-67标记指数(Ki-67labelingindex,Ki-67LI)。结果:Ki-67平均标记指数为53%,Ki-67LI随着Ed-mondson-Steiner分级的增加而增高;中位生存期Ki-67低表达组显著高于高表达组(P<0.05);Ki-67LI高分化肝细胞癌组织与无瘤肝组织比较差异无统计学意义。结论:Ki-67LI与肝细胞癌组织学特征显著相关,是反映肝亚段动脉化学栓塞术后的客观的预后指标。Objective:To explore the relationship between the efficacy of subsegmental TACE and Ki-67labeling index in31HCCs.Methods:Ultrasound-guided tumor needle biopsies were per-formed before TACE in31patients.An assessment was made of proliferative activity by immunohisto-chemical staining using a monoclonal antibody against Ki-67in all patients.A correlation between Ki-67labeling index and the efficacy of TACE and clinicopathologic finding or prognosis was sought.Re -sults:The mean labeling index of Ki-67was53%in HCC.The labeling index increased with the in-creased Edmendson-Steiner grades.The survival rate after TACE was significantly higher(P<0.05)in the low labeling index group than in the high labeling index group.No significant correlation was ob-served between the labeling index of well differentiated HCC and nontumor liver tissue.Conclusion:The Ki-67labeling index is shown to be closely related to histologic characteristics,and proved to be a useful indicator of survival in HCC.

关 键 词：肝细胞瘤 抗原Ki-67 栓塞 治疗性 

分 类 号：R735.7[医药卫生—肿瘤] R730.53[医药卫生—临床医学]