胃复安治疗Tourette综合征对智力、记忆功能的影响  

Effects of metoclopramide on intelligence and memory in patients with Tourette syndrome

作　　者：叶海翠[1] 谢小玲[1] 游泳[1] 彭旭[1] 伍大华[1] 罗文凤[1] 

机构地区：[1]中南大学湘雅医院神经内科,长沙410078

出　　处：《湖南医科大学学报》2003年第3期301-303,共3页Bulletin of Hunan Medical University

基　　金：湖南省卫生厅资助课题 ( 9916)

摘　　要：目的 :探讨胃复安对治疗前、后Tourette综合征 (TS)患儿的智力及记忆功能的影响。方法 :采用韦氏儿童智力量表 (C WISC)、韦氏儿童记忆量表甲式 (WMS CR)对 2 5例TS患儿分别在胃复安治疗前及治疗 3个月后进行智力和记忆功能测试 ,并进行治疗前后自身比较。结果 :智力测验中胃复安治疗后患儿的智力水平由 82 .2 7± 1 3.2 0提高到 90 .5 3± 1 5 .5 0 ,差异非常显著 ,特别是操作智商由 84 .1 3± 1 0 .6 0升至 92 .4 0± 1 5 .30 ,差异显著 ,其中负荷于记忆 /不分心因子的算术分测验量表分由 8.2 0± 2 .70升至 1 0 .2 0± 3.2 1 ,负荷于知觉组织因子的木块图分测验量表分由 9.1 3± 2 .33升至 1 0 .5 3± 2 .94 ;而记忆测验中胃复安治疗后负荷于短时记忆的视觉再认分测验量表分由治疗前的 6 .0 7± 4 .5 6升至 8.4 0± 3.5 6 ,差异显著。结论 :胃复安治疗后患儿的智力水平有明显提高 ,特别是对记忆 /不分心因子及知觉组织因子的改善 。Objective To investigate the effects of metoclopramide on the intelligence and memory in patients with Tourette syndrome.Methods Before and after the 3 month treatment of metoclopramide, the intelligence of 25 children with Tourette syndrome was evaluated by the Wechsler intelligence scale for children,and the memory by the Wechsler memory scale for children.Results The scores of intelligence in children treated by metoclopramide increased from 82.27±13.20 to 90.53±15.50, with significant difference ( P <0.05).The scores of performance intelligence quotient increased from 84.13±10.60 to 92.40±15.30 ( P <0.01). The scores of arithmetic subtle test for the support memory/attention, the block pattern subtle test for the support perception constitution factor, and the vision recognition subtle test for mean short term memory increased from 8.20±2.70 to 10.20±3.21, 9.13±2.33 to 10.53±2.94,and 6.07±4.56 to 8.40±3.56, respectively. Conclusion Metoclopramide can improve the intelligence, short term memory and attention in children with Tourette syndrome.

关 键 词：胃复安 治疗 TOURETTE综合征 智力 记忆功能 影响 

分 类 号：R748[医药卫生—神经病学与精神病学]