COX-2在直肠腺瘤性息肉与癌组织中的表达及意义  

Expression of COX-2 and its significance in rectal familial adenomatous polyposis and rectal cancer tissues

作　　者：廖湘鲁[1] 王兴武[1] 国前[1] 魏玲[1] 管杰[1] 田国栋[1] 

机构地区：[1]山东省肿瘤防治研究院基础研究中心,山东济南250117

出　　处：《中国癌症杂志》2003年第3期250-252,共3页China Oncology

摘　　要：目的 :研究COX 2在直肠家族性腺瘤性息肉病 (familialadenomatouspolyposis,FAP)与癌组织中的表达及意义。方法 :用流式细胞仪 (FCM )分别检测 1 2例正常直肠粘膜组织、1 9例FAP、7例FAP癌变组织及 36例直肠癌组织的COX 2蛋白表达。结果 :1 2例正常直肠粘膜组织COX 2蛋白表达的平均FI值为 0 .67± 0 .2 8,均呈阴性表达 ;FAP 1 8(94.74% )例、FAP癌变组织 7(1 0 0 % )例及直肠癌组织 36 (1 0 0 % )例阳性表达 ,COX 2蛋白表达平均FI值分别为 1 .97± 0 .36、2 .0 2± 0 .2 4、2 .1 4± 0 .31 ,COX 2蛋白表达及阳性表达率与正常直肠粘膜组织差异均有显著性 (P <0 .0 1 ) ,而三者之间差异无显著性 (P >0 .0 5)。结论 :提示COX 2蛋白表达检测对预测腺瘤性息肉癌变可能性。Purpose:To study COX 2 protein expression and its significance in familial adenomatous polyposis (FAP) and rectal cancer tissues. Methods: Flow cytometry was used to detect COX 2 protein expression in surgical specimens from 12 normal rectal mucosa tissues, 19 FAP tissues, 7 transformed FAP tissues and 36 rectal cancer tissues.Results:The COX 2 protein expression was negative in the 12 normal rectal mucosa tissues ( FI=0.67±0.28). The COX 2 protein expression was positive in 18 (94.74%) of the 19 FAP tissues (FI=1.97±0.36),the 7(100%) transformed FAP tissues(FI=2.02±0.24) and the 36(100%) rectal cancer tissues (FI=2.14±0.31). The COX 2 protein and positive expression rates showed that there were obvious differences between normal rectal mucosa tissues and FAP tissues, transformed FAP tissues, rectal cancer tissues( P <0.01). There were no differences among FAP tissues and transformed FAP tissues and rectal cancer tissues( P >0.05). Conclusions:It is suggested that the detection of COX 2 protein expression can have important significance for predicting adenomatous polyposis carceration and chemo interfering carceration progress. [

关 键 词：COX-2 直肠腺瘤性息肉 癌组织 表达 

分 类 号：R735.37[医药卫生—肿瘤]