核因子-κB及其相关调控基因的表达与大肠癌临床病理指标的关系  

Expression of NF-κB, c-myc and ICAM-1 in colorectal cancer and its relation to the indices in clinical pathology

作　　者：吴斌[1] 王元正[1] 魏仁志[1] 徐亮[1] 周业江[1] 

机构地区：[1]泸州医学院附属医院普外科,四川泸州646000

出　　处：《中国癌症杂志》2003年第3期225-228,共4页China Oncology

摘　　要：目的 :探讨核因子 κB及其相关调控基因表达与大肠癌临床病理指标的关系。方法 :采用免疫组化S P法测定 50例大肠癌组织中NF κBp65及其相关调控基因c myc和ICAM 1的表达。 结果 :①正常结肠组织中NF κBp65有微弱表达 ,c myc和ICAM 1无表达 ;大肠癌组织中NF κBp65、c myc和ICAM 1的表达明显强于正常结肠组织 (P <0 .0 5)。②大肠癌组织中NF κBp65、ICAM 1的表达在有转移时比无转移显著增强 (P <0 .0 5) ;NF κBp65、c myc和ICAM 1在组织分化差的大肠癌中表达较分化好的表达显著增高 (P <0 .0 5) ;DukesC +D期的表达显著高于A +B期 (P <0 .0 5) ;而不同年龄、性别以及肿瘤发生部位的大肠癌组织中NF κBp65、c myc和ICAM 1表达没有差异 (P 0 .0 5)。结论 :NF κB、c myc和ICAM 1与大肠癌的发生、转移有密切关系 。Purpose:To investigate the expression of nuclear factor kappa binding (NF κBp65),c myc and intercellular adhesion molecule 1(ICAM 1) in colorectal cancer and its relation to clinicopathology.Methods:50 colorectal cancer patients who underwent radical surgery were studied, the expression of NF κBp65, c myc and ICAM 1 in them were examined by immunohistochemical method.Results:①In normal colon there was weak expression of NF κBp65, no expression of c myc and ICAM 1, NF kBp65,C myc and ICAM 1 were strongly expressed in colorectal cancer than in normal colon( P <0.01) ②NF κBp65 ,ICAM 1 were more strongly expressed in the colorectal cancer with metastasis than those without metastasis( P <0.01), NF kBp65, c myc and ICAM 1 in poorly differentiated tumor tissues were more strongly expressed than in well differentiated tumor tissues( P <0.01), in Dukes C+D were strongly expressed than in A+B. The expression of NF κBp65 was not related to age, sex and tumor origin, c myc was not related to age, sex, tumor origin and metastasis, and ICAM 1 was not related to age, sex, tumor spot and differentiate Conclusions:The expression of NF κBp65, c myc and ICAM 1 has relation with the occurrence and metastasis of colorectal cancer and will became the marker of metastasis in colorectal cancer. [

关 键 词：核因子-KB 调控基因 表达 大肠癌 病理 细胞间粘附分子 

分 类 号：R735.34[医药卫生—肿瘤]