^(103)Pd种子源植入治疗肿瘤近期疗效观察  

Effect of permanent ^(103) Pd radioactive seed implantation on brachytherapy of malignant tumor

作　　者：陈萍[1] 魏献忠[1] 刘衍民[2] 吴开俊[2] 梁健新[3] 陈汉章[4] 

机构地区：[1]广州医学院第一附属医院核医学科,510120 [2]广州医学院第一附属医院微创中心,510120 [3]广州医学院第一附属医院耳鼻喉科,510120 [4]广州医学院第一附属医院胸外科,510120

出　　处：《中华核医学杂志》2003年第3期152-153,共2页Chinese Journal of Nuclear Medicine

基　　金：广州市科技局资助项目 (JB0 2 2 0 0 1 2 0 36 0 1 3)

摘　　要：目的　评估1 0 3Pd种子源植入治疗恶性肿瘤的近期疗效。方法　 2 1例确诊的恶性肿瘤患者 ,由治疗计划系统 (TPS)通过不同术式植入1 0 3Pd种子源 (196 .1～ 2 12 7.5MBq) ,其中 15例采用均一布源 ,6例前列腺癌采用中心消融 ,外周布源。观察肿瘤大小、局部复发和远处转移情况 ;并按肿瘤放射协作组 欧洲肿瘤研究及治疗 (RTOG EORTC)急性或后期放疗副作用评分标准进行评分。结果随访期内 2 1例患者均未见局部复发和远处转移 ,RTOG EORTC评分为 0分 19例 ,占 90 .5 % ,1分 2例 ,占 9.5 %。结论　1 0 3Pd种子源植入治疗肿瘤近期效果安全可行。Objective To investigate and assess the brachytherapeutic effectiveness of 103 Pd radioactive seeds in malignant tumor therapy. Methods 196.1～2 127.5 MBq 103 Pd seeds were implanted in 21 confirmed malignant tumor patients. The seeds were evenly scattered in 15/21 patients' tumors and peripherally in the remaining 6 cases' tumors. The size and shape, local recurrence and remote metastasis of the tumors were observed. Results The brachytherapy of 103 Pd seeds in tumor patients resulted in obvious efficacy. No local recurrence and remote metastasis were observed. 19/21(90.5%) patients scored 0 and 2/21(9.5%) of them scored 1 in skin acute radiation morbidity scoring criteria within the observation period. Conclusion The 103 Pd seeds can be safely used in brachytherapy of malignant tumors with lower or medium sensitivity to radiation therapy.

关 键 词：肿瘤 ^103Pd种子源植入 治疗 疗效观察 近距离放射疗法 

分 类 号：R730.5[医药卫生—肿瘤]